Anti-Nipped-B-like protein NIPBL Antibody

• Description:

  Boster Bio Anti-Nipped-B-like protein NIPBL Antibody catalog # A01939. Tested in IHC applications. This antibody reacts with Human, Mouse.

• Synonyms:

  Nipped-B-like protein; Delangin; SCC2 homolog; NIPBL; IDN3, SCC2

• Gene Name:

  NIPBL

• UniProt:

  Q6KC79

• Host:

  Rabbit

• Reactivity:

  Human, Mouse

• Immunogen:

  Synthesized peptide derived from human protein at AA range: 560-640

• Clonality:

  Polyclonal

• Tissue Specificity:

  Widely expressed. Highly expressed in heart, skeletal muscle, fetal and adult liver, fetal and adult kidney. Expressed at intermediates level in thymus, placenta, peripheral leukocyte and small intestine. Weakly or not expressed in brain, colon, spleen and lung.

• Applications:

  IHC

• Purification:

  NIPBL antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

• Concentration:

  1 mg/ml

• Dilution:

  IHC-p 1:50-300

• Form:

  Liquid

• Function:

  Plays an important role in the loading of the cohesin complex on to DNA. Forms a heterodimeric complex (also known as cohesin loading complex) with MAU2/SCC4 which mediates the loading of the cohesin complex onto chromatin (PubMed:22628566, PubMed:28914604) . Plays a role in cohesin loading at sites of DNA damage. Its recruitement to double-strand breaks (DSBs) sites occurs in a CBX3-, RNF8- and RNF168-dependent manner whereas its recruitement to UV irradiation-induced DNA damage sites occurs in a ATM-, ATR-, RNF8- and RNF168-dependent manner (PubMed:28167679) . Along with ZNF609, promotes cortical neuron migration during brain development by regulating the transcription of crucial genes in this process. Preferentially binds promoters containing paused RNA polymerase II. Up-regulates the expression of SEMA3A, NRP1, PLXND1 and GABBR2 genes, among others (By similarity) .

• Molecular Weight:

  316051 MW

• Shipping Conditions:

  Available

• Storage Conditions:

  Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.

• Fragment:

  IgG

• Other Gene Names:

  Nipped-B-like protein

• Subcellular Location:

  Nucleus

• Protein Name:

  Nipped-B-like protein