Anti-Netrin receptor UNC5B UNC5B Antibody

• Description:

  Boster Bio Anti-Netrin receptor UNC5B UNC5B Antibody catalog # A03986. Tested in ELISA, WB applications. This antibody reacts with Human, Mouse, Rat.

• Synonyms:

  Netrin receptor UNC5B; Protein unc-5 homolog 2; Protein unc-5 homolog B; p53-regulated receptor for death and life protein 1

• Gene Name:

  UNC5B

• UniProt:

  Q8IZJ1

• Host:

  Rabbit

• Reactivity:

  Human, Mouse, Rat

• Immunogen:

  Synthesized peptide derived from human protein at AA range: 350-430

• Clonality:

  Polyclonal

• Tissue Specificity:

  Highly expressed in brain. Also expressed at lower level in developing lung, cartilage, kidney and hematopoietic and immune tissues.

• Applications:

  WB, ELISA

• Purification:

  UNC5B antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

• Concentration:

  1 mg/ml

• Dilution:

  WB 1:500-2000 ELISA 1:5000-20000

• Form:

  Liquid

• Function:

  Receptor for netrin required for axon guidance. Mediates axon repulsion of neuronal growth cones in the developing nervous system upon ligand binding. Axon repulsion in growth cones may be caused by its association with DCC that may trigger signaling for repulsion (By similarity) . Functions as netrin receptor that negatively regulates vascular branching during angiogenesis. Mediates retraction of tip cell filopodia on endothelial growth cones in response to netrin (By similarity) . It also acts as a dependence receptor required for apoptosis induction when not associated with netrin ligand (PubMed:12598906) . Mediates apoptosis by activating DAPK1. In the absence of NTN1, activates DAPK1 by reducing its autoinhibitory phosphorylation at Ser-308 thereby increasing its catalytic activity (By similarity) .

• Molecular Weight:

  103638 MW

• Shipping Conditions:

  Available

• Storage Conditions:

  Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.

• Fragment:

  IgG

• Other Gene Names:

  Netrin receptor UNC5B

• Subcellular Location:

  Cell membrane

• Protein Name:

  Netrin receptor UNC5B