Anti-Hu CD209 Purified Monoclonal Antibody

• Background:

  CD209, also known as DC-SIGN (dendritic cell-specific ICAM-3-grabbing nonintegrin) is a transmembrane receptor expressed on the surface of dendritic cells and macrophages, which recognizes numerous pathogens ranging from parasites to viruses. Its N-terminal domain is transmembrane, whereas a tandem-repeat neck domain and the C terminal C-type lectin carbohydrate recognition domain have dual function as a pathogen recognition receptor and a cell adhesion receptor. The neck region is responsible for homo-oligomerization which allows the receptor to bind multivalent ligands with high avidity. A ligand of CD209 is also CD50 (ICAM-3) .

• Description:

  Boster Bio Anti-Hu CD209 Purified Monoclonal Antibody (Catalog# M01025-2) . Tested in Flow Cytometry, IHC, ICC application (s) . This antibody reacts with Human.

• Synonyms:

  CLEC4L, DC-SIGN1, CDSIGN

• Gene Name:

  CD209

• UniProt:

  Q9NNX6

• Host:

  Mouse

• Reactivity:

  Human

• Immunogen:

  CD209-His-tagged fusion protein. The mouse monoclonal antibody UW60.1 recognizes an extracellular epitope of human CD209 (DC-SIGN), a 44 kDa transmembrane receptor, expressed on the surface of dendritic cells and macrophages.

• Clonality:

  Monoclonal

• Clone:

  Clone: UW60.1

• Tissue Specificity:

  Predominantly expressed in dendritic cells and in DC-residing tissues. Also found in placental macrophages, endothelial cells of placental vascular channels, peripheral blood mononuclear cells, and THP-1 monocytes.

• Applications:

  Flow Cytometry, IHC, ICC

• Purification:

  Purified by protein-A affinity chromatography.

• Concentration:

  1 mg/ml

• Dilution:

  Flow cytometry: 1-4 μg/ml.

• Form:

  Liquid

• Function:

  Pathogen-recognition receptor expressed on the surface of immature dendritic cells (DCs) and involved in initiation of primary immune response. Thought to mediate the endocytosis of pathogens which are subsequently degraded in lysosomal compartments. The receptor returns to the cell membrane surface and the pathogen-derived antigens are presented to resting T-cells via MHC class II proteins to initiate the adaptive immune response.

• Molecular Weight:

  45775 MW

• Shipping Conditions:

  Available

• Storage Conditions:

  Store at 2-8°C. Do not freeze.

• Fragment:

  Mouse IgG2a

• Other Gene Names:

  CD209 molecule

• Subcellular Location:

  Isoform 1: Cell membrane; Single-pass type II membrane protein.

• Protein Name:

  CD209 antigen