Anti-PD1 PDCD1 Monoclonal Antibody [4D6]

• Background:

  Cell-mediated immune responses are initiated by T lymphocytes that are themselves stimulated by cognate peptides bound to MHC molecules on antigen-presenting cells (APC) . T-cell activation is generally self-limited as activated T cells express receptors such as PD-1 (also known as PDCD-1) that mediate inhibitory signals from the APC. PD-1 can bind two different but related ligands, PDL-1 and PDL-2. Upon binding to either of these ligands, signals generated by PD-1 inhibit the activation of the immune response in the absence of "danger signals" such as LPS or other molecules associated with bacteria or other pathogens. Evidence for this is seen in PD-1-null mice who exhibit hyperactivated immune systems and autoimmune diseases. PD-1 is thus one of a growing number of immune checkpoint proteins.

• Description:

  Boster Bio Anti-PD1 PDCD1 Monoclonal Antibody [4D6] (Catalog # M00178-4) . Tested in ELISA, WB, IHC-P, ICC, IF applications. This antibody reacts with Human.

• Synonyms:

  PD1, PD-1, CD279, SLEB2, hPD-1, hPD-l, hSLE1, PD1, Programmed cell death protein 1, Protein PD-1, PDCD1, PDCD-1

• Gene Name:

  PDCD1

• UniProt:

  Q15116

• Host:

  Mouse

• Reactivity:

  Human

• Immunogen:

  PD-1 antibody was raised against the extracellular domain of human PD-1.

• Clonality:

  Monoclonal

• Clone:

  Clone: Clone: 4D6

• Applications:

  ELISA, WB, IHC-P, ICC, IF

• Field of Research:

  Immunology

• Purification:

  PD-1 Antibody is supplied as protein A purified IgG1.

• Concentration:

  1 mg/mL

• Form:

  Liquid

• Function:

  Inhibitory cell surface receptor involved in the regulation of T-cell function during immunity and tolerance. Upon ligand binding, inhibits T-cell effector functions in an antigen- specific manner. Possible cell death inducer, in association with other factors.

• Molecular Weight:

  31647 MW

• Shipping Conditions:

  Available

• Storage Conditions:

  PD-1 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. Avoid repeated freeze-thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Fragment:

  IgG1

• Other Gene Names:

  Programmed cell death 1

• Subcellular Location:

  Membrane; Single-pass type I membrane protein.

• Protein Name:

  Programmed cell death 1