Anti-TAU MAPT Antibody

• Background:

  The microtubial-associated protein TAU (MAPT), more commonly known as TAU, is is normally a highly soluble protein found predominantly in neurons (1), but accumulations of highly phosphorylated tau protein aggregates are observed in several neurodegenerative diseases including Alzheimer's disease, progressive supranuclear palsy, corticobasal degeneration, and frontotemporal lobar dementia. It was thought that these pathological tau aggregates were the toxic form of tau, but recent studies indicate that soluble and highly phosphorylated tau species are more closely associated with synaptic dysfunction and cell loss (2,3) . Mutations in the TAU gene have also been associated with several of these neurodegenerative diseases (4) .

• Description:

  Boster Bio Anti-TAU MAPT Antibody (Catalog # A00097) . Tested in ELISA, WB, IHC-P applications. This antibody reacts with Human, Mouse, Rat.

• Synonyms:

  Microtubial-associated protein tau, MAPT, MAPTL, DDPAC, FTDP-17L, MSTD, MTBT1, MTBT2, PPND, PPP1R103

• Gene Name:

  TAU

• UniProt:

  P10636

• Host:

  Rabbit

• Reactivity:

  Human, Mouse, Rat

• Cross Reactivity:

  TAU antibody is human, mouse and rat reactive. Multiple isoforms of TAU are known to exist; this antibody will only detect the two longest isoforms.

• Immunogen:

  TAU antibody was raised against a 19 amino acid peptide near the amino terminus of human TAU. The immunogen is located within amino acids 210 - 260 of TAU.

• Clonality:

  Polyclonal

• Tissue Specificity:

  Expressed in neurons. Isoform PNS-tau is expressed in the peripheral nervous system while the others are expressed in the central nervous system.

• Applications:

  ELISA, WB, IHC-P

• Field of Research:

  Neuroscience

• Purification:

  TAU antibody is affinity chromatography purified via peptide column.

• Concentration:

  1 mg/mL

• Form:

  Liquid

• Function:

  Promotes microtubule assembly and stability, and might be involved in the establishment and maintenance of neuronal polarity. The C-terminus binds axonal microtubules while the N- terminus binds neural plasma membrane components, suggesting that tau functions as a linker protein between both. Axonal polarity is predetermined by TAU/MAPT localization (in the neuronal cell) in the domain of the cell body defined by the centrosome. The short isoforms allow plasticity of the cytoskeleton whereas the longer isoforms may preferentially play a role in its stabilization.

• Molecular Weight:

  78928 MW

• Shipping Conditions:

  Available

• Storage Conditions:

  TAU antibody can be stored at 4°C for three months and -20°C, stable for up to one year.

• Fragment:

  IgG

• Other Gene Names:

  Microtubule-associated protein tau

• Subcellular Location:

  Cytoplasm, cytosol

• Protein Name:

  Microtubule-associated protein tau