Anti-ATM interactor ATMIN Antibody

• Background:

  The ATM/ATR-substrate CHK2-interacting zinc finger protein (ATMIN), also known as ASCIZ, forms DNA damage-induced nuclear foci that contain the DNA repair protein Rad51 (1) . ATMIN is also thought to be involved in embryonic development, as an absence of ATMIN causes late-embryonic lethality in mice with a range of organ development defects (2) . It also activates the transcription DYNLL1, a light chain of the dynein motor complex and sequence-specific regulator of protein dimerization of numerous targets. DYNLL1 can bind to and inhibit the transcription activation domain of ATMIN, forming a simple dynamic feedback loop for DYNLL1 expression (3) .

• Description:

  Boster Bio Anti-ATM interactor ATMIN Antibody (Catalog # A06542) . Tested in ELISA, WB, ICC, IF applications. This antibody reacts with Human, Mouse, Rat.

• Synonyms:

  ASCIZ, ZNF822, KIAA0431, ATM interactor, Zinc finger protein 822, ASCIZ

• Gene Name:

  ATMIN

• UniProt:

  O43313

• Host:

  Rabbit

• Reactivity:

  Human, Mouse, Rat

• Cross Reactivity:

  ATMIN antibody is human, mouse and rat reactive. At least three isoforms of ATMIN are known to exist.

• Immunogen:

  ATMIN antibody was raised against a 19 amino acid peptide near the amino terminus of human ATMIN. The immunogen is located within amino acids 200 - 250 of ATMIN.

• Clonality:

  Polyclonal

• Tissue Specificity:

  Ubiquitously expressed in normal tissues and cancer cell lines with highest levels in placenta and skeletal muscle.

• Applications:

  ELISA, WB, ICC, IF

• Field of Research:

  Stem Cells

• Purification:

  ATMIN antibody is affinity chromatography purified via peptide column.

• Concentration:

  1 mg/mL

• Form:

  Liquid

• Function:

  Transcription factor. Plays a crucial role in cell survival and RAD51 foci formation in response to methylating DNA damage. Involved in regulating the activity of ATM in the absence of DNA damage. May play a role in stabilizing ATM. Binds to the DYNLL1 promoter and activates its transcription.

• Molecular Weight:

  88348 MW

• Shipping Conditions:

  Available

• Storage Conditions:

  ATMIN antibody can be stored at 4°C for three months and -20°C, stable for up to one year.

• Fragment:

  IgG

• Other Gene Names:

  ATM interactor

• Subcellular Location:

  Nucleus

• Protein Name:

  ATM interactor