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Anti-PRRT2 Antibody

CAT: 0519-A02707Size: 0.1 mgDry Ice: NoHazardous: No
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CAT#:0519-A02707Size:0.1 mg
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Background
The proline-rich transmembrane protein 2 (PRRT2) contains a proline-rich domain in its N-terminal half and is predominantly expressed in brain and spinal cord in embryonic and postnatal stages. While little is known of the function of this protein, mutations in PRRT2 have been shown to be the causative gene of paroxysmal kinesigenic dyskinesia, which is characterized by recurrent, brief attacks of abnormal involuntary movements induced by sudden voluntary movements. Recent studies have shown that PRRT2 may also be involved in some forms of benign familial infantile epilepsy (BFIE), an autosomal dominant epilepsy syndrome.
Description
Boster Bio Anti-PRRT2 Antibody (Catalog # A02707) . Tested in ELISA, WB, IHC-P, IF applications. This antibody reacts with Human, Mouse, Rat.
Synonyms
PKC, EKD1, ICCA, BFIC2, BFIS2, DSPB3, DYT10, FICCA, IFITMD1, Proline-rich transmembrane protein 2, Dispanin subfamily B member 3
Gene Name
PRRT2
UniProt
Q7Z6L0
Host
Rabbit
Reactivity
Human, Mouse, Rat
Cross Reactivity
Multiple isoforms of PRRT2 are known to exist.
Immunogen
PRRT2 antibody was raised against a 18 amino acid peptide near the center of human PRRT2 . The immunogen is located within amino acids 180 - 230 of PRRT2.
Clonality
Polyclonal
Applications
ELISA, WB, IHC-P, IF
Field of Research
Stem Cells
Purification
PRRT2 Antibody is affinity chromatography purified via peptide column.
Concentration
1 mg/mL
Form
Liquid
Function
As a component of the outer core of AMPAR complex, may be involved in synaptic transmission in the central nervous system. In hippocampal neurons, in presynaptic terminals, plays an important role in the final steps of neurotransmitter release, possibly by regulating Ca (2+) -sensing. In the cerebellum, may inhibit SNARE complex formation and downregulate short-term facilitation.
Molecular Weight
34945 MW
Shipping Conditions
Available
Storage Conditions
PRRT2 antibody can be stored at 4°C for three months and -20°C, stable for up to one year.
Fragment
IgG
Other Gene Names
Proline-rich transmembrane protein 2
Subcellular Location
Cell membrane
Protein Name
Proline-rich transmembrane protein 2

UniProtKB · Q7Z6L0

Proline-rich transmembrane protein 2

PRRT2_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
Q7Z6L0
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
PRRT2
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
—
EC number
—
Processing
—
Secondary accessions
A8K8M8, Q8N2N8, Q8NAQ7, Q8ND36, Q96FA8
Protein keywords

Coding sequence diversity

Alternative splicing

Cellular component

Cell membraneCell projectionCytoplasmic vesicleMembranePostsynaptic cell membraneSynapse

Disease

Disease variantDystoniaEpilepsy

PTM

MethylationPhosphoprotein

Technical term

Proteomics identificationReference proteome

Domain

TransmembraneTransmembrane helix

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