Anti-CD59 glycoprotein CD59 Antibody

• Background:

  The complement regulatory protein CD59 is a cell surface glycoprotein that regulates complement-mediated cell lysis and is involved in lymphocyte signal transduction. CD59 is a potent inhibitor of the complement membrane attack complex, whereby it binds complement C8 and/or C9 during the assembly of this complex, thereby inhibiting the incorporation of multiple copies of C9 into the complex, which is necessary for osmolytic pore formation. CD59 also plays a role in signal transduction pathways in the activation of T cells. Mutations in this gene cause CD59 deficiency, a disease resulting in hemolytic anemia and thrombosis, and ultimately cerebral infarction.

• Description:

  Boster Bio Anti-CD59 glycoprotein CD59 Antibody (Catalog # A00914-1) . Tested in ELISA, WB applications. This antibody reacts with Human, Mouse.

• Synonyms:

  1F5, EJ16, EJ30, EL32, G344, MIN1, MIN2, MIN3, MIRL, HRF20, MACIF, MEM43, MIC11, MSK21, 16.3A5, HRF-20, MAC-IP, p18-20, CD59 glycoprotein, 1F5 antigen

• Gene Name:

  CD59

• UniProt:

  P13987

• Host:

  Rabbit

• Reactivity:

  Human, Mouse

• Immunogen:

  Rabbit polyclonal CD59 antibody was raised against a 14 amino acid peptide near the amino terminus of human CD59. The immunogen is located within the first 50 amino acids of CD59.

• Clonality:

  Polyclonal

• Applications:

  ELISA, WB

• Field of Research:

  Immunology

• Purification:

  CD59 Antibody is affinity chromatography purified via peptide column.

• Concentration:

  1 mg/mL

• Form:

  Liquid

• Function:

  Potent inhibitor of the complement membrane attack complex (MAC) action. Acts by binding to the C8 and/or C9 complements of the assembling MAC, thereby preventing incorporation of the multiple copies of C9 required for complete formation of the osmolytic pore. This inhibitor appears to be species-specific. Involved in signal transduction for T-cell activation complexed to a protein tyrosine kinase.

• Molecular Weight:

  14177 MW

• Shipping Conditions:

  Available

• Storage Conditions:

  CD59 antibody can be stored at 4°C for three months and -20°C, stable for up to one year.

• Fragment:

  IgG

• Other Gene Names:

  CD59 molecule, complement regulatory protein

• Subcellular Location:

  Cell membrane; Lipid-anchor, GPI-anchor. Secreted. Soluble form found in a number of tissues.

• Prediction Reactivity:

  Pig

• Protein Name:

  CD59 molecule, complement regulatory protein