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Anti-Coronin 7 CORO7 Antibody

CAT: 0519-A11552Size: 0.1 mgDry Ice: NoHazardous: No
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CAT#:0519-A11552Size:0.1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
Coronins, such as Coronin 7, constitute an evolutionarily conserved family of WD-repeat actin-binding proteins whose function is thought to be regulating the cytoskeleton. Unlike other cytoplasmically localized Coronins, Coronin 7 localizes in part to the Golgi complex and is thought to play a role in Golgi complex morphology and function. Other experiments indicate that Coronin 7 interacts with the anti-proliferative protein TOB1 and enhances its degradation though the SCF ubiquitin ligase (E3) complex.
Description
Boster Bio Anti-Coronin 7 CORO7 Antibody (Catalog # A11552) . Tested in ELISA, WB, IHC-P, IF applications. This antibody reacts with Human, Mouse, Rat.
Synonyms
CRN7, POD1, 0610011B16Rik, Coronin-7, 70 kDa WD repeat tumor rejection antigen homolog, Crn7
Gene Name
CORO7
UniProt
P57737
Host
Rabbit
Reactivity
Human, Mouse, Rat
Cross Reactivity
Multiple isoforms of Coronin 7 are known to exist
Immunogen
Coronin 7 antibody was raised against an 17 amino acid synthetic peptide near the carboxy terminus of human Coronin 7. The immunogen is located within the last 50 amino acids of Coronin 7.
Clonality
Polyclonal
Tissue Specificity
Widely expressed. Expressed in the spleen, peripheral leukocytes, testes, brain, thymus and small intestine.
Applications
ELISA, WB, IHC-P, IF
Field of Research
Homeostasis
Purification
Coronin 7 Antibody is affinity chromatography purified via peptide column.
Concentration
1 mg/mL
Form
Liquid
Function
F-actin regulator involved in anterograde Golgi to endosome transport: upon ubiquitination via 'Lys-33'-linked ubiquitin chains by the BCR (KLHL20) E3 ubiquitin ligase complex, interacts with EPS15 and localizes to the trans-Golgi network, where it promotes actin polymerization, thereby facilitating post- Golgi trafficking. May play a role in the maintenance of the Golgi apparatus morphology.
Molecular Weight
100605 MW
Shipping Conditions
Available
Storage Conditions
Coronin 7 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. Avoid repeated freeze-thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Fragment
IgG
Other Gene Names
Coronin7
Subcellular Location
Golgi apparatus membrane. Golgi apparatus, trans-Golgi network. Cytoplasmic vesicle . Cytoplasm, cytosol . Predominantly cytosolic. Detected on vesicle-like cytoplasmic structures and on the cis-Golgi. Not associated with actin filaments.
Prediction Reactivity
Bovine
Protein Name
Coronin7

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