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Anti-ORM1-like protein 1 ORMDL1 Antibody

CAT: 0519-A12278Size: 0.1 mgDry Ice: NoHazardous: No
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CAT#:0519-A12278Size:0.1 mg
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Background
The ORMDL (ORM1-like) family of proteins consist of ORMDL1, ORMDL2 and ORMDL3 that may play roles in gamma-secretase complex maturation. Localized to the membrane of the endoplasmic reticulum, ORMDLs are widely expressed and are implicated in the expression of Presenilin (PSI) which is involved in Alzheimer's disease (AD) . Expression of ORMDL1 is down-regulated in PSI mutations, suggesting a possible role as a therapeutic target for AD. ORMDLs have recently been identified as a potential risk factor for childhood asthma.
Description
Boster Bio Anti-ORM1-like protein 1 ORMDL1 Antibody (Catalog # A12278) . Tested in ELISA, WB, IHC-P, IF applications. This antibody reacts with Human, Mouse, Rat.
Synonyms
ORM1-like protein 1, Adoplin-1
Gene Name
ORMDL1
UniProt
Q9P0S3
Host
Rabbit
Reactivity
Human, Mouse, Rat
Cross Reactivity
ORMDL1 antibody may cross-react with other ORMDL protein family members.
Immunogen
ORMDL1 antibody was raised against a 16 amino acid synthetic peptide of human ORMDL1. The immunogen is located within amino acids 50 - 100 of ORMDL1.
Clonality
Polyclonal
Tissue Specificity
Widely expressed. Expressed in adult and fetal heart, brain, lung, liver, skeletal muscle and kidney. Expressed in adult pancreas and placenta and in fetal spleen abd thymus. Expressed at intermediate level in pancreas, placenta and brain but low in skeletal muscle and lung.
Applications
ELISA, WB, IHC-P, IF
Field of Research
Neuroscience
Purification
ORMDL1 Antibody is affinity chromatography purified via peptide column.
Concentration
1 mg/mL
Form
Liquid
Function
Negative regulator of sphingolipid synthesis.
Molecular Weight
17371 MW
Shipping Conditions
Available
Storage Conditions
ORMDL1 antibody can be stored at 4 °C, stable for one year. Avoid repeated freeze-thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Fragment
IgG
Other Gene Names
ORM1-like 1 (S. cerevisiae)
Subcellular Location
Endoplasmic reticulum membrane
Prediction Reactivity
Bovine, Chicken
Protein Name
ORM1-like 1 (S. cerevisiae)

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