Anti-ZNF346 (CT) Antibody

• Background:

  ZNF346, also known as JAZ (just another zinc-finger protein), is a nucleolar, zinc finger protein which preferentially binds to double-stranded (ds) RNA or RNA/DNA hybrids with high affinity via C2H2 zinc fingers. ZNF346 contains four CH-type zinc finger motifs that are connected by long (28-38) amino acid linker sequences. ZNF346 is expressed in all tissues tested and localizes to the nucleus, primarily the nucleolus. ZNF346 is exported by exportin-5 but translocates back into nuclei by a facilitated diffusion mechanism. ZNF346 interacts with ILF3 in an RNA-independent manner and may be involved in cell growth and survival.

• Description:

  Boster Bio Anti-ZNF346 (CT) Antibody (Catalog # A09984-1) . Tested in ELISA, WB, IHC-P, IF applications. This antibody reacts with Human, Mouse.

• Synonyms:

  JAZ, Zfp346, JAZ, Zinc finger protein 346, Just another zinc finger protein

• Gene Name:

  ZNF346

• UniProt:

  Q9UL40

• Host:

  Rabbit

• Reactivity:

  Human, Mouse

• Cross Reactivity:

  ZNF346 antibody is predicted to not cross-react with other ZNF family members. Three isoforms of ZNF346 are known to exist; this antibody will recognize the two longest isoforms

• Immunogen:

  ZNF346 antibody was raised against a 20 amino acid synthetic peptide near the carboxy terminus of human ZNF346. The immunogen is located within the last 50 amino acids of ZNF346.

• Clonality:

  Polyclonal

• Applications:

  ELISA, WB, IHC-P, IF

• Field of Research:

  Cancer, Cell Cycle

• Purification:

  ZNF346 (CT) Antibody is affinity chromatography purified via peptide column.

• Concentration:

  1 mg/mL

• Form:

  Liquid

• Function:

  Binds with low affinity to dsDNA and ssRNA, and with high affinity to dsRNA, with no detectable sequence specificity (PubMed:24521053) . May bind to specific miRNA hairpins (PubMed:28431233) .

• Molecular Weight:

  32933 MW

• Shipping Conditions:

  Available

• Storage Conditions:

  ZNF346 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. Avoid repeated freeze-thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Fragment:

  IgG

• Other Gene Names:

  Zinc finger protein 346

• Subcellular Location:

  Nucleus, nucleolus

• Protein Name:

  Zinc finger protein 346