Anti-Prolyl 3-hydroxylase OGFOD1 OGFOD1 Antibody

• Background:

  OGFOD1, a member of the 2-OG-Fe (II) dioxygenase family, plays an important role in ischemic survival and stress. It is an oxidoreductase containing a Prolyl 4-hydroxylase alpha subunit. An OGFOD1 iron binding residue is required for ATPAF1 gene expression. As a novel stress granule component, OGFOD1 plays important proapoptotic roles in the regulation of translation and HRI-mediated phosphorylation of eIF2alpha in cells.

• Description:

  Boster Bio Anti-Prolyl 3-hydroxylase OGFOD1 OGFOD1 Antibody (Catalog # A09074) . Tested in ELISA, WB, IF applications. This antibody reacts with Human, Mouse.

• Synonyms:

  TPA1, KIAA1612, TPA1, 2-oxoglutarate and iron-dependent oxygenase domain-containing protein 1, Termination and polyadenylation 1 homolog

• Gene Name:

  OGFOD1

• UniProt:

  Q8N543

• Host:

  Rabbit

• Reactivity:

  Human, Mouse

• Cross Reactivity:

  OGFOD1 antibody is predicted to not cross-react with other TPA1 protein family members. At least two isoforms are known to exist; this antibody will only detect the larger isform.

• Immunogen:

  OGFOD1 antibody was raised against a 18 amino acid synthetic peptide near the carboxy terminus of human OGFOD1. The immunogen is located within the first 50 amino acids of OGFOD1.

• Clonality:

  Polyclonal

• Applications:

  ELISA, WB, IF

• Field of Research:

  Apoptosis

• Purification:

  OGFOD1 Antibody is affinity chromatography purified via peptide column.

• Concentration:

  1 mg/mL

• Form:

  Liquid

• Function:

  Prolyl 3-hydroxylase that catalyzes 3-hydroxylation of 'Pro-62' of small ribosomal subunit uS12 (RPS23), thereby regulating protein translation termination efficiency. Involved in stress granule formation.

• Molecular Weight:

  63246 MW

• Shipping Conditions:

  Available

• Storage Conditions:

  OGFOD1 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. Avoid repeated freeze-thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Fragment:

  IgG

• Other Gene Names:

  2-oxoglutarate and iron-dependent oxygenase domain containing 1

• Subcellular Location:

  Isoform 1: Cytoplasm. Nucleus. Mainly nuclear. A portion relocalizes to cytoplasmic stress granules upon stress.

• Prediction Reactivity:

  Bovine

• Protein Name:

  2-oxoglutarate and iron-dependent oxygenase domain containing 1