Anti-Prosapip1 LZTS3 Antibody

• Background:

  Prosapip1 is a binding partner of the postsynaptic density (PSD) protein ProSAP2/Shank3, a major scaffolding protein in excitatory brain synapses. Prosapip1 is thought to bind ProSAP2/Shank3 through ProSAP2/Shank3's PDZ domain and link it in turn to the Spine-associated Rap-Gap (SPAR) . Prosapip1 shares significant homology with another PSD protein, PSD-Zip70, with both coding for a Fez1 domain that can be found in a total of four related protein, forming a novel family of scaffolding molecules termed ‘Fezzins'. Recent studies show that Prosapip1 can be found in endocrine cells in which it is localized primarily in the hormone-storing compartment of these cells, suggesting that Prosapip1 may have other functions in non-neuronal cells.

• Description:

  Boster Bio Anti-Prosapip1 LZTS3 Antibody (Catalog # A14930) . Tested in ELISA, WB, IHC-P, IF applications. This antibody reacts with Human, Mouse, Rat.

• Synonyms:

  PROSAPIP1, KIAA0552, PROSAPIP1, Leucine zipper putative tumor suppressor 3, ProSAP-interacting protein 1, ProSAPiP1

• Gene Name:

  PROSAPIP1

• UniProt:

  O60299

• Host:

  Rabbit

• Reactivity:

  Human, Mouse, Rat

• Immunogen:

  Prosapip1 antibody was raised against a 16 amino acid synthetic peptide from near the carboxy terminus of human Prosapip1. The immunogen is located within amino acids 590 - 640 of Prosapip1.

• Clonality:

  Polyclonal

• Applications:

  ELISA, WB, IHC-P, IF

• Field of Research:

  Neuroscience

• Purification:

  Prosapip1 Antibody is affinity chromatography purified via peptide column.

• Concentration:

  1 mg/mL

• Form:

  Liquid

• Function:

  May be involved in promoting the maturation of dendritic spines, probably via regulating SIPA1L1 levels at the postsynaptic density of synapses.

• Molecular Weight:

  71791 MW

• Shipping Conditions:

  Available

• Storage Conditions:

  Prosapip1 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. Avoid repeated freeze-thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Fragment:

  IgG

• Other Gene Names:

  ProSAPiP1 protein

• Subcellular Location:

  Cell junction, synapse

• Protein Name:

  ProSAPiP1 protein