Anti-Interferon-inducible GTPase 5 IRGC Antibody

• Background:

  Immunity-related GTPases (IRG) (also known as p47 GTPases) are a family of GTPase proteins found in vertebrates, which play critical roles in mediating innate resistance to intracellular pathogens. IRG genes have been found in a number of mammals and lower species including mice, rats, zebrafish and humans. Most of the mouse genes contain interferon-stimulated response elements which mediate transcriptional activation by IFNs. In humans, only two IRG genes have been found: human IRGC encodes a full-length IRG protein that, like the mouse homologue, is constitutively expressed in testis, while human IRGM encodes a considerably truncated protein that is constitutively expressed in cultured cells including some macrophage cell lines. As the two human genes IRGC and IRGM are not subject to IFN control, it has been suggested that the host resistance mechanism supported by IRG proteins in the mouse is lacking in humans.

• Description:

  Boster Bio Anti-Interferon-inducible GTPase 5 IRGC Antibody (Catalog # A14937) . Tested in ELISA, WB, ICC, IF applications. This antibody reacts with Human, Mouse, Rat.

• Synonyms:

  IFGGE, IRGC1, Iigp5, CINEMA, R30953_1, IIGP5, Interferon-inducible GTPase 5, Immunity-related GTPase cinema 1

• Gene Name:

  IRGC

• UniProt:

  Q6NXR0

• Host:

  Rabbit

• Reactivity:

  Human, Mouse, Rat

• Cross Reactivity:

  Two isoforms of IRGC are known to exist; this antibody will recognize both isoforms.

• Immunogen:

  IRGC antibody was raised against a 12 amino acid synthetic peptide near the carboxy terminus of human IRGC. The immunogen is located within the last 50 amino acids of IRGC.

• Clonality:

  Polyclonal

• Applications:

  ELISA, WB, ICC, IF

• Field of Research:

  Innate Immunity

• Purification:

  IRGC Antibody is affinity chromatography purified via peptide column.

• Concentration:

  1 mg/mL

• Form:

  Liquid

• Molecular Weight:

  50288 MW

• Shipping Conditions:

  Available

• Storage Conditions:

  IRGC antibody can be stored at 4°C for three months and -20°C, stable for up to one year. Avoid repeated freeze-thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Fragment:

  IgG

• Other Gene Names:

  Immunity-related GTPase family, cinema

• Protein Name:

  Immunity-related GTPase family, cinema