Anti-IFN-beta IFNB1 Antibody

• Background:

  Type I Interferons (IFN-alpha/beta) are produced primarily in response to viral infection by "Natural IFN-producing cells" (IPCs) as part of the host immune response and can also inhibit the development of tumors. IFN-beta binding by its receptor results in the activation of the tyrosine kinases Jak1 and Tyk2 and phosphorylation of members of the STAT family of transcription factors, leading to the transcription and expression of the immune response genes. More recently, several members of the toll-like receptor (TLR) family were found to stimulate the production IFN-beta. IFN-beta is currently used clinically for treatment of tumors, infections and multiple sclerosis.

• Description:

  Boster Bio Anti-IFN-beta IFNB1 Antibody (Catalog # A02041-1) . Tested in ELISA, WB, IHC-P, IF applications. This antibody reacts with Human, Mouse, Rat.

• Synonyms:

  IFB, IFF, IFNB, IFB, Interferon beta, Fibroblast interferon, IFN-beta

• Gene Name:

  IFNB1

• UniProt:

  P01574

• Host:

  Rabbit

• Reactivity:

  Human, Mouse, Rat

• Immunogen:

  Anti-IFN-beta antibody was raised against a peptide corresponding to 17 amino acids near the center of human IFN-beta. The immunogen is located within amino acids 110-160 of IFN-beta.

• Clonality:

  Polyclonal

• Tissue Specificity:

  High expression in testis and thymus, less in colon, spleen, lung and small intestine. Expressed in fetal thymus, bone marrow, heart, liver, spleen and thymus. Expression is associated with cells/tissues with a high mitotic index.

• Applications:

  ELISA, WB, IHC-P, IF

• Field of Research:

  Immunology, Inflammasomes

• Purification:

  IFN-beta Antibody is affinity chromatography purified via peptide column.

• Concentration:

  1 mg/mL

• Form:

  Liquid

• Function:

  Has antiviral, antibacterial and anticancer activities.

• Molecular Weight:

  22294 MW

• Shipping Conditions:

  Available

• Storage Conditions:

  IFN-beta antibody can be stored at 4°C up to one year. Antibodies should not be exposed to prolonged high temperatures.

• Fragment:

  IgG

• Other Gene Names:

  Interferon, beta 1, fibroblast

• Subcellular Location:

  Secreted.

• Protein Name:

  Interferon, beta 1, fibroblast