Anti-PD-1 PDCD1 Antibody

• Background:

  Cell-mediated immune responses are initiated by T lymphocytes that are themselves stimulated by cognate peptides bound to MHC molecules on antig en-presenting cells (APC) . T-cell activation is generally self-limited as activated T cells express receptors such as PD-1 (also known as PDCD-1) that mediate inhibitory signals from the APC. PD-1 can bind two different but related ligands, PDL-1 and PDL-2. Upon binding to either of these ligands, signals generated by PD-1 inhibit the activation of the immune response in the absence of "danger signals" such as LPS or other molecules associated with bacteria or other pathogens. Evidence for this is seen in PD1-null mice who exhibit hyperactivated immune systems and autoimmune diseases.

• Description:

  Boster Bio Anti-PD-1 PDCD1 Antibody (Catalog # A00178-1) . Tested in ELISA, WB, IHC-P, ICC, IF applications. This antibody reacts with Human, Mouse, Rat.

• Synonyms:

  PD1, PD-1, CD279, SLEB2, hPD-1, hPD-l, hSLE1, PD1, Programmed cell death protein 1, Protein PD-1

• Gene Name:

  PDCD1

• UniProt:

  Q15116

• Host:

  Rabbit

• Reactivity:

  Human, Mouse, Rat

• Immunogen:

  PD-1 antibody was raised against a 16 amino acid synthetic peptide from near the center of human PD-1. The immunogen is located within amino acids 120 - 170 of PD-1.

• Clonality:

  Polyclonal

• Tissue Specificity:

  Highly expressed in heart, placenta, pancreas, lung and liver and weakly expressed in spleen, lymph nodes and thymus.

• Applications:

  ELISA, WB, IHC-P, ICC, IF

• Field of Research:

  Apoptosis

• Purification:

  PD-1 Antibody is affinity chromatography purified via peptide column.

• Concentration:

  1 mg/mL

• Form:

  Liquid

• Function:

  Inhibitory cell surface receptor involved in the regulation of T-cell function during immunity and tolerance. Upon ligand binding, inhibits T-cell effector functions in an antigen- specific manner. Possible cell death inducer, in association with other factors.

• Molecular Weight:

  31647 MW

• Shipping Conditions:

  Available

• Storage Conditions:

  PD-1 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. Avoid repeated freeze-thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Fragment:

  IgG

• Other Gene Names:

  Programmed cell death 1

• Subcellular Location:

  Membrane; Single-pass type I membrane protein.

• Protein Name:

  Programmed cell death 1