Anti-IL-23 Antibody

• Background:

  Like interleukin-27 (IL-27), IL-23 is a recently discovered member of the IL-6/IL-12 family of proinflammatory and immunoregulatory cytokines. It exists as a heterodimer composed of the IL-12p40 subunit and a novel p19 subunit. IL-23 is secreted by activated dendritic cells, macrophages, and monocytes. Its biological activities include enhancing the proliferation of memory T cells and the production of IFN-gamma, IL-12, and TNF-α from activated T cells, and can stimulate macrophages to produce TNF-α and nitric oxide. It has also been shown to possess potent anti-tumor and anti-metastatic activity in mouse models of cancer, suggesting a potential role for IL-23 in therapeutic treatment of cancer.

• Description:

  Boster Bio Anti-IL-23 Antibody (Catalog # A01097-2) . Tested in ELISA, WB, IHC-P, IF applications. This antibody reacts with Human, Mouse.

• Synonyms:

  P19, SGRF, IL-23, IL-23A, IL23P19, UNQ2498/PRO5798, Interleukin-23 subunit alpha, Interleukin-23 subunit p19, IL-23 subunit alpha

• Gene Name:

  IL23A

• UniProt:

  Q9NPF7

• Host:

  Rabbit

• Reactivity:

  Human, Mouse

• Immunogen:

  Anti-IL-23 antibody was raised against a peptide corresponding to 17 amino acids near the amino terminus of human IL-23. The immunogen is located within amino acids 40 - 90 of IL-23.

• Clonality:

  Polyclonal

• Tissue Specificity:

  Secreted by activated dendritic and phagocytic cells and keratinocytes. Also expressed by dermal Langerhans cells (at protein level) .

• Applications:

  ELISA, WB, IHC-P, IF

• Field of Research:

  Immunology, Chemokines, Cytokines, Neuroscience

• Purification:

  IL-23 Antibody is affinity chromatography purified via peptide column.

• Concentration:

  1 mg/mL

• Form:

  Liquid

• Function:

  Associates with IL12B to form the IL-23 interleukin, a heterodimeric cytokine which functions in innate and adaptive immunity. IL-23 may constitute with IL-17 an acute response to infection in peripheral tissues. IL-23 binds to a heterodimeric receptor complex composed of IL12RB1 and IL23R, activates the Jak- Stat signaling cascade, stimulates memory rather than naive T- cells and promotes production of proinflammatory cytokines. IL-23 induces autoimmune inflammation and thus may be responsible for autoimmune inflammatory diseases and may be important for tumorigenesis.

• Molecular Weight:

  20730 MW

• Shipping Conditions:

  Available

• Storage Conditions:

  IL-23 antibody can be stored at 4°C up to one year. Antibodies should not be exposed to prolonged high temperatures.

• Fragment:

  IgG

• Other Gene Names:

  Interleukin 23, alpha subunit p19

• Subcellular Location:

  Secreted

• Prediction Reactivity:

  Horse, Pig, Rat, Guinea Pig

• Protein Name:

  Interleukin 23, alpha subunit p19