Anti-CRMP1 Antibody

• Background:

  Collapsin-response mediator proteins (CRMPs) are highly expressed in the developing brain where they play major roles in axonal outgrowth, neurite differentiation, and apoptosis. Their continued expression in areas of high synaptic remodeling such as the cerebellum, hippocampus, and the olfactory system suggests that these proteins may also be involved in adult brain plasticity. CRMP-1 was initially identified as a dihydro-pyrimidinase expressed exclusively in brain; later studies have shown that it is involved with neurotrophin (NT) 3-induced neurite formation and outgrowth. CRMP-1 localization switches from axonal to somatodendritic when neurons reach functional maturity, suggesting that it is involved in early neuronal differentiation as well as in later processes related to the survival or death of the newly generated neurons.

• Description:

  Boster Bio Anti-CRMP1 Antibody (Catalog # A05002) . Tested in ELISA, WB, IHC-P, IF applications. This antibody reacts with Human, Mouse, Rat.

• Synonyms:

  DRP1, DRP-1, CRMP-1, DPYSL1, ULIP-3, ULIP3, Dihydropyrimidinase-related protein 1, Collapsin response mediator protein 1

• Gene Name:

  CRMP1

• UniProt:

  Q14194

• Host:

  Rabbit

• Reactivity:

  Human, Mouse, Rat

• Immunogen:

  CRMP1 antibody was raised against a 15 amino acid synthetic peptide from near the carboxy terminus of human CRMP1. The immunogen is located within the last 50 amino acids of CRMP1.

• Clonality:

  Polyclonal

• Tissue Specificity:

  Brain.

• Applications:

  ELISA, WB, IHC-P, IF

• Field of Research:

  Neuroscience

• Purification:

  CRMP1 Antibody is affinity chromatography purified via peptide column.

• Concentration:

  1 mg/mL

• Form:

  Liquid

• Function:

  Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. Plays a role in axon guidance, invasive growth and cell migration. May participate in cytokinesis.

• Molecular Weight:

  62184 MW

• Shipping Conditions:

  Available

• Storage Conditions:

  CRMP1 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. Avoid repeated freeze-thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Fragment:

  IgG

• Other Gene Names:

  Collapsin response mediator protein 1

• Subcellular Location:

  Cytoplasm

• Protein Name:

  Collapsin response mediator protein 1