Anti-IKK gamma IKBKG Antibody

• Background:

  Nuclear factor kappa B (NF-κB) is a ubiquitous transcription factor and an essential mediator of gene expression during activation of immune and inflammatory responses. NF-κB mediates the expression of a great variety of genes in response to extracellular stimuli. NF-κB is associated with IκB proteins in the cell cytoplasm, which inhibit NF-κB activity. The IκB kinase (IKKα and IKKβ ) phosphorylates IkB and mediates NF-κB activation. A novel molecule in the IKK complex was recently identified and termed IKKγ /NEMO/FIP3/IKKAP1. IKKγ interacts with IKKβ and is required for the activation of IKK complex and NF-κB by LPS, PMA, TNF, and IL-1 stimulation. FIP3 was also shown to bind to RIP and NIK and to mediate TNF-induced NF-κB activation.

• Description:

  Boster Bio Anti-IKK gamma IKBKG Antibody (Catalog # A00874-2) . Tested in ELISA, WB, ICC, IF applications. This antibody reacts with Human, Mouse, Rat.

• Synonyms:

  IP, IP1, IP2, FIP3, IPD2, NEMO, FIP-3, Fip3p, AMCBX1, ZC2HC9, IKK-gamma, NF-kappa-B essential modulator

• Gene Name:

  IKBKG

• UniProt:

  Q9Y6K9

• Host:

  Rabbit

• Reactivity:

  Human, Mouse, Rat

• Cross Reactivity:

  IKK gamma has no cross response to IKK alpha or IKK beta.

• Immunogen:

  IKK gamma antibody was raised against a 17 amino acid peptide near the carboxy terminus of human IKK gamma. The immunogen is located within the last 50 amino acids of IKK gamma.

• Clonality:

  Polyclonal

• Tissue Specificity:

  Heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas.

• Applications:

  ELISA, WB, ICC, IF

• Field of Research:

  Signal Transduction

• Purification:

  IKK gamma Antibody is DEAE purified.

• Concentration:

  1 mg/ml

• Form:

  Liquid

• Function:

  Regulatory subunit of the IKK core complex which phosphorylates inhibitors of NF-kappa-B thus leading to the dissociation of the inhibitor/NF-kappa-B complex and ultimately the degradation of the inhibitor. Its binding to scaffolding polyubiquitin seems to play a role in IKK activation by multiple signaling receptor pathways. However, the specific type of polyubiquitin recognized upon cell stimulation (either 'Lys-63'- linked or linear polyubiquitin) and its functional importance is reported conflictingly. Also considered to be a mediator for TAX activation of NF-kappa-B. Could be implicated in NF-kappa-B- mediated protection from cytokine toxicity. Essential for viral activation of IRF3. Involved in TLR3- and IFIH1-mediated antiviral innate response; this function requires 'Lys-27'-linked polyubiquitination.

• Molecular Weight:

  48198 MW

• Shipping Conditions:

  Available

• Storage Conditions:

  IKK gamma antibody can be stored at 4°C for three months and -20°C, stable for up to one year. Avoid repeated freeze-thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Fragment:

  IgG

• Other Gene Names:

  Inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma

• Subcellular Location:

  Cytoplasm

• Prediction Reactivity:

  Bovine

• Protein Name:

  Inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma