Anti-CBR1 Rabbit Monoclonal Antibody

• Description:

  Boster Bio Anti-CBR1 Rabbit Monoclonal Antibody catalog # M02825-3. Tested in WB, IHC, ICC/IF applications. This antibody reacts with Human.

• Synonyms:

  Mitogen-activated protein kinase 7; MAP kinase 7; MAPK 7;2.7.11.24; Big MAP kinase 1; BMK-1; Extracellular signal-regulated kinase 5; ERK-5; MAPK7; BMK1, ERK5, PRKM7

• Gene Name:

  Mitogen-activated protein kinase 7

• UniProt:

  P16152

• Host:

  Rabbit

• Reactivity:

  Human

• Immunogen:

  A synthesized peptide derived from human CBR1

• Clonality:

  Monoclonal

• Clone:

  Clone: 30C98

• Tissue Specificity:

  Expressed in many adult tissues. Abundant in heart, placenta, lung, kidney and skeletal muscle. Not detectable in liver. .

• Applications:

  WB, IHC, ICC, IF

• Field of Research:

  Intracellular Signaling, Kinases, MAPK Pathway, Neural Signal Transduction, Neurology Process, Neuroscience, Neurotransmission, Protein Phosphorylation, Ser/Thr Kinases, Signal Transduction

• Purification:

  Affinity-chromatography

• Concentration:

  Actual concentration vary by lot. Use suggested dilution ratio to decide dilution procedure.

• Form:

  Liquid

• Reconstitution:

  Restore with deionized water (or equivalent) for reconstitution volume of 1.0 mL

• Function:

  Plays a role in various cellular processes such as proliferation, differentiation and cell survival. The upstream activator of MAPK7 is the MAPK kinase MAP2K5. Upon activation, it translocates to the nucleus and phosphorylates various downstream targets including MEF2C. EGF activates MAPK7 through a Ras- independent and MAP2K5-dependent pathway. May have a role in muscle cell differentiation. May be important for endothelial function and maintenance of blood vessel integrity. MAP2K5 and MAPK7 interact specifically with one another and not with MEK1/ERK1 or MEK2/ERK2 pathways. Phosphorylates SGK1 at Ser-78 and this is required for growth factor-induced cell cycle progression. Involved in the regulation of p53/TP53 by disrupting the PML-MDM2 interaction. .

• Storage Conditions:

  Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.

• Fragment:

  IgG

• Applications Notes:

  WB 1:500-1:2000
  IHC 1:50-1:200
  ICC/IF 1:50-1:200

• Other Gene Names:

  CBR1

• Subcellular Location:

  Cytoplasm. Nucleus. Nucleus, PML body. Translocates to the nucleus upon activation.

• Protein Name:

  T-cell surface glycoprotein CD3 zeta chain