Anti-Erlin-2 Rabbit Monoclonal Antibody

• Description:

  Boster Bio Anti-Erlin-2 Rabbit Monoclonal Antibody catalog # M07042. Tested in WB, IHC, ICC/IF applications. This antibody reacts with Human, Mouse.

• Synonyms:

  MAD2L1-binding protein; Caught by MAD2 protein; MAD2L1BP; CMT2, KIAA0110

• Gene Name:

  MAD2L1-binding protein

• UniProt:

  O94905

• Host:

  Rabbit

• Reactivity:

  Human, Mouse

• Immunogen:

  A synthesized peptide derived from human Erlin-2

• Clonality:

  Monoclonal

• Clone:

  Clone: 26E96

• Tissue Specificity:

  Expressed in a discontinuous manner in the basal cell layer of adult skin epidermis, but continuously in the basal layer of fetal skin epidermis and nail. Also expressed in the outer root sheath above the hair bulb in hair follicle (at protein level) . Expressed homogeneously in all cell layers of the esophagus and exocervix, but detected in the basal cell layer only of oral mucosa, skin and in the basal plus the next two layers of the suprabasal epithelium of the palate. .

• Applications:

  WB, IHC, ICC, IF

• Field of Research:

  Alzheimer's Disease, Cell Adhesion Proteins, Cell Type Marker, Cytoskeleton, Cytoskeleton/ECM, Developmental Biology, Intermediate Filaments, Lineage Markers, Lineage Specification, Neurodegenerative Disease, Neurology Process, Neuron Marker, Neuroscience, Signal Transduction, Stem Cells

• Purification:

  Affinity-chromatography

• Concentration:

  Actual concentration vary by lot. Use suggested dilution ratio to decide dilution procedure.

• Form:

  Liquid

• Reconstitution:

  Restore with deionized water (or equivalent) for reconstitution volume of 1.0 mL

• Function:

  May function to silence the spindle checkpoint and allow mitosis to proceed through anaphase by binding MAD2L1 after it has become dissociated from the MAD2L1-CDC20 complex. .

• Storage Conditions:

  Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.

• Fragment:

  IgG

• Applications Notes:

  WB 1:500-1:2000
  IHC 1:50-1:200
  ICC/IF 1:50-1:200

• Other Gene Names:

  ERLIN2

• Subcellular Location:

  Nucleus. Cytoplasm, cytoskeleton, spindle. During early mitosis, unevenly distributed throughout the nucleoplasm. From metaphase to anaphase, concentrated on the spindle.

• Protein Name:

  T-cell surface glycoprotein CD3 zeta chain