Anti-TRAP1 Rabbit Monoclonal Antibody

• Description:

  Boster Bio Anti-TRAP1 Rabbit Monoclonal Antibody catalog # M02426-4. Tested in WB, IHC, ICC/IF applications. This antibody reacts with Human.

• Synonyms:

  Heat shock protein 75 kDa, mitochondrial; HSP 75; TNFR-associated protein 1; Tumor necrosis factor type 1 receptor-associated protein; TRAP-1; TRAP1; HSP75

• Gene Name:

  Heat shock protein 75 kDa, mitochondrial

• UniProt:

  Q12931

• Host:

  Rabbit

• Reactivity:

  Human

• Immunogen:

  A synthesized peptide derived from human TRAP1

• Clonality:

  Monoclonal

• Clone:

  Clone: 23T98

• Tissue Specificity:

  Found in skeletal muscle, liver, heart, brain, kidney, pancreas, lung, placenta and bladder. Expression is higly reduced in bladder cancer and renal cell carcinoma specimens compared to healthy tissues, but it is increased in other type of tumors. .

• Applications:

  WB, IHC, ICC, IF

• Field of Research:

  Apoptosis, Cancer, Cell Biology, Cell Death, Chaperones, Heat Shock Proteins, Metabolism, Metabolism Processes, Mitochondrial, Mitochondrial Markers, Mitochondrial Metabolism, Pathways and Processes, Protein Trafficking, Signal Transduction

• Purification:

  Affinity-chromatography

• Concentration:

  Actual concentration vary by lot. Use suggested dilution ratio to decide dilution procedure.

• Form:

  Liquid

• Reconstitution:

  Restore with deionized water (or equivalent) for reconstitution volume of 1.0 mL

• Function:

  Chaperone that expresses an ATPase activity. Involved in maintaining mitochondrial function and polarization, most likely through stabilization of mitochondrial complex I. Is a negative regulator of mitochondrial respiration able to modulate the balance between oxidative phosphorylation and aerobic glycolysis. The impact of TRAP1 on mitochondrial respiration is probably mediated by modulation of mitochondrial SRC and inhibition of SDHA. .

• Storage Conditions:

  Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.

• Fragment:

  IgG

• Applications Notes:

  WB 1:1000-1:5000
  IHC 1:50-1:200
  ICC/IF 1:100-1:500

• Other Gene Names:

  TRAP1

• Subcellular Location:

  Mitochondrion . Mitochondrion inner membrane . Mitochondrion matrix .

• Protein Name:

  T-cell surface glycoprotein CD3 zeta chain