Anti-ASS1 Rabbit Monoclonal Antibody

• Description:

  Boster Bio Anti-ASS1 Rabbit Monoclonal Antibody catalog # M02212-3. Tested in WB, IHC, ICC/IF, IP, Flow Cytometry applications. This antibody reacts with Human, Mouse, Rat.

• Synonyms:

  Caspase-10; CASP-10;3.4.22.63; Apoptotic protease Mch-4; FAS-associated death domain protein interleukin-1B-converting enzyme 2; FLICE2; ICE-like apoptotic protease 4; Caspase-10 subunit p23/17; Caspase-10 subunit p12; CASP10; MCH4

• Gene Name:

  Caspase-10

• UniProt:

  P00966

• Host:

  Rabbit

• Reactivity:

  Human, Mouse, Rat

• Immunogen:

  A synthesized peptide derived from human ASS1

• Clonality:

  Monoclonal

• Clone:

  Clone: 23A63

• Tissue Specificity:

  Detectable in most tissues. Lowest expression is seen in brain, kidney, prostate, testis and colon.

• Applications:

  WB, IHC, ICC, IF, IP, Flow Cytometry

• Field of Research:

  Adaptive Immunity, Alzheimer's Disease, Cancer, Cell Biology, Cell Cycle, Cell Division, Chromatin Remodeling, Chromosome Structure, Epigenetics and Nuclear Signaling, ER Proteins, Immunology, Neurodegenerative Disease, Neurology Process, Neuroscience, Oncoproteins, Oncoproteins/Suppressors, Protein Phosphorylation, Protein Trafficking, Ser/Thr Phosphatases, Signal Transduction, T Cells

• Purification:

  Affinity-chromatography

• Concentration:

  Actual concentration vary by lot. Use suggested dilution ratio to decide dilution procedure.

• Form:

  Liquid

• Reconstitution:

  Restore with deionized water (or equivalent) for reconstitution volume of 1.0 mL

• Function:

  Involved in the activation cascade of caspases responsible for apoptosis execution. Recruited to both Fas- and TNFR-1 receptors in a FADD dependent manner. May participate in the granzyme B apoptotic pathways. Cleaves and activates caspase- 3, -4, -6, -7, -8, and -9. Hydrolyzes the small- molecule substrates, Tyr-Val-Ala-Asp-|-AMC and Asp-Glu-Val-Asp-|-AMC. .

• Storage Conditions:

  Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.

• Fragment:

  IgG

• Applications Notes:

  WB 1:500-1:2000
  IHC 1:50-1:200
  ICC/IF 1:50-1:200
  IP 1:50
  FC 1:500

• Other Gene Names:

  ASS1

• Subcellular Location:

  Cytoplasm. Nucleus. Cell membrane. Membrane, clathrin-coated pit . Cell projection, pseudopodium . Cytoplasmic vesicle. Translocates to the plasma membrane and colocalizes with antagonist-stimulated GPCRs. The monomeric form is predominantly located in the nucleus. The oligomeric form is located in the cytoplasm. Translocates to the nucleus upon stimulation of OPRD1 (By similarity) . .

• Protein Name:

  Lysosome-associated membrane glycoprotein 2 (Lamp2)