Anti-IL7R alpha/CD127 Rabbit Monoclonal Antibody

• Description:

  Boster Bio Anti-IL7R alpha/CD127 Rabbit Monoclonal Antibody catalog # M02222. Tested in WB, Flow Cytometry applications. This antibody reacts with Human, Mouse, Rat.

• Synonyms:

  CD276 antigen;4Ig-B7-H3; B7 homolog 3; B7-H3; Costimulatory molecule; CD276; CD276; B7H3; PSEC0249, UNQ309/PRO352

• Gene Name:

  CD276 antigen

• UniProt:

  P16871

• Host:

  Rabbit

• Reactivity:

  Human, Mouse, Rat

• Immunogen:

  A synthesized peptide derived from human IL7R alpha/CD127

• Clonality:

  Monoclonal

• Clone:

  Clone: 22I71

• Tissue Specificity:

  Ubiquitous but not detectable in peripheral blood lymphocytes or granulocytes. Weakly expressed in resting monocytes. Expressed in dendritic cells derived from monocytes. Expressed in epithelial cells of sinonasal tissue. Expressed in extravillous trophoblast cells and Hofbauer cells of the first trimester placenta and term placenta. .

• Applications:

  WB, Flow Cytometry

• Field of Research:

  Developmental Families, Domain Families, Epigenetics and Nuclear Signaling, Neural Signal Transduction, Neurogenesis, Neurology Process, Neuroscience, Transcription

• Purification:

  Affinity-chromatography

• Concentration:

  Actual concentration vary by lot. Use suggested dilution ratio to decide dilution procedure.

• Form:

  Liquid

• Reconstitution:

  Restore with deionized water (or equivalent) for reconstitution volume of 1.0 mL

• Function:

  May participate in the regulation of T-cell-mediated immune response. May play a protective role in tumor cells by inhibiting natural-killer mediated cell lysis as well as a role of marker for detection of neuroblastoma cells. May be involved in the development of acute and chronic transplant rejection and in the regulation of lymphocytic activity at mucosal surfaces. Could also play a key role in providing the placenta and fetus with a suitable immunological environment throughout pregnancy. Both isoform 1 and isoform 2 appear to be redundant in their ability to modulate CD4 T-cell responses. Isoform 2 is shown to enhance the induction of cytotoxic T-cells and selectively stimulates interferon gamma production in the presence of T-cell receptor signaling. .

• Storage Conditions:

  Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.

• Fragment:

  IgG

• Applications Notes:

  WB 1:500-1:2000
  FC 1:100

• Other Gene Names:

  IL7R

• Subcellular Location:

  Membrane ; Single-pass type I membrane protein .

• Protein Name:

  Lysosome-associated membrane glycoprotein 2 (Lamp2)