Anti-RING1 Rabbit Monoclonal Antibody

• Description:

  Boster Bio Anti-RING1 Rabbit Monoclonal Antibody catalog # M01824-1. Tested in WB, IHC, ICC/IF applications. This antibody reacts with Human.

• Synonyms:

  Midkine; MK; Amphiregulin-associated protein; ARAP; Midgestation and kidney protein; Neurite outgrowth-promoting factor 2; Neurite outgrowth-promoting protein; MDK; MK1, NEGF2

• Gene Name:

  Midkine

• UniProt:

  Q06587

• Host:

  Rabbit

• Reactivity:

  Human

• Immunogen:

  A synthesized peptide derived from human RING1

• Clonality:

  Monoclonal

• Clone:

  Clone: 22R33

• Tissue Specificity:

  Expressed in various tumor cell lines. In insulinoma tissue predominantly expressed in precancerous lesions. .

• Applications:

  WB, IHC, ICC, IF

• Field of Research:

  Growth and Development, Neurogenesis, Neurology Process, Neuroscience

• Purification:

  Affinity-chromatography

• Concentration:

  Actual concentration vary by lot. Use suggested dilution ratio to decide dilution procedure.

• Form:

  Liquid

• Reconstitution:

  Restore with deionized water (or equivalent) for reconstitution volume of 1.0 mL

• Function:

  Developmentally regulated, secreted growth factor homologous to pleiotrophin (PTN), which has heparin binding activity. Binds anaplastic lymphoma kinase (ALK) which induces ALK activation and subsequent phosphorylation of the insulin receptor substrate (IRS1), followed by the activation of mitogen-activated protein kinase (MAPK) and PI3-kinase, and the induction of cell proliferation. Involved in neointima formation after arterial injury, possibly by mediating leukocyte recruitment. Also involved in early fetal adrenal gland development (By similarity) . .

• Storage Conditions:

  Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.

• Fragment:

  IgG

• Applications Notes:

  WB 1:500-1:2000
  IHC 1:50-1:200
  ICC/IF 1:50-1:200

• Other Gene Names:

  RING1

• Subcellular Location:

  Secreted.

• Protein Name:

  Lysosome-associated membrane glycoprotein 2 (Lamp2)