Anti-SMN1 Rabbit Monoclonal Antibody

• Description:

  Boster Bio Anti-SMN1 Rabbit Monoclonal Antibody catalog # M03420-2. Tested in WB, IHC, IP applications. This antibody reacts with Human, Mouse, Rat.

• Synonyms:

  Chondroitin sulfate proteoglycan 4; Chondroitin sulfate proteoglycan NG2; Melanoma chondroitin sulfate proteoglycan; Melanoma-associated chondroitin sulfate proteoglycan; CSPG4; MCSP

• Gene Name:

  Chondroitin sulfate proteoglycan 4

• UniProt:

  Q16637

• Host:

  Rabbit

• Reactivity:

  Human, Mouse, Rat

• Immunogen:

  A synthesized peptide derived from human SMN1

• Clonality:

  Monoclonal

• Clone:

  Clone: 19S71

• Tissue Specificity:

  Detected only in malignant melanoma cells. .

• Applications:

  WB, IHC, IP

• Field of Research:

  Apoptosis, Associated Proteins, Calcium Binding Proteins, Calcium Signaling, Cancer, Cell Biology, Cell Death, Cytoskeleton, Cytoskeleton/ECM, Microtubules, Receptors, Signal Transduction, Signaling Pathway

• Purification:

  Affinity-chromatography

• Concentration:

  Actual concentration vary by lot. Use suggested dilution ratio to decide dilution procedure.

• Form:

  Liquid

• Reconstitution:

  Restore with deionized water (or equivalent) for reconstitution volume of 1.0 mL

• Function:

  Proteoglycan playing a role in cell proliferation and migration which stimulates endothelial cells motility during microvascular morphogenesis. May also inhibit neurite outgrowth and growth cone collapse during axon regeneration. Cell surface receptor for collagen alpha 2 (VI) which may confer cells ability to migrate on that substrate. Binds through its extracellular N- terminus growth factors, extracellular matrix proteases modulating their activity. May regulate MPP16-dependent degradation and invasion of type I collagen participating in melanoma cells invasion properties. May modulate the plasminogen system by enhancing plasminogen activation and inhibiting angiostatin. Functions also as a signal transducing protein by binding through its cytoplasmic C-terminus scaffolding and signaling proteins. May promote retraction fiber formation and cell polarization through Rho GTPase activation. May stimulate alpha-4, beta-1 integrin- mediated adhesion and spreading by recruiting and activating a signaling cascade through CDC42, ACK1 and BCAR1. May activate FAK and ERK1/ERK2 signaling cascades. .

• Storage Conditions:

  Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.

• Fragment:

  IgG

• Applications Notes:

  WB 1:500-1:2000
  IHC 1:50-1:200
  IP 1:50

• Other Gene Names:

  SMN1

• Subcellular Location:

  Cell membrane ; Single-pass type I membrane protein ; Extracellular side . Apical cell membrane ; Single-pass type I membrane protein ; Extracellular side . Cell projection, lamellipodium membrane ; Single-pass type I membrane protein ; Extracellular side . Cell surface . Localized at the apical plasma membrane it relocalizes to the lamellipodia of astrocytoma upon phosphorylation by PRKCA. Localizes to the retraction fibers. Localizes to the plasma membrane of oligodendrocytes (By similarity) . .

• Protein Name:

  T-cell surface glycoprotein CD3 zeta chain