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Human GDF 5 Protein

CAT: 0749-PRP1073-01Size: 5 µgDry Ice: NoHazardous: No
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CAT#:0749-PRP1073-01Size:5 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
Human GDF-5 is expressed in long bones during embryonic development and postnatally in articular cartilage. Mutations in the Human GDF-5 gene have been implicated in Hunter-Thompson type dwarfism and in Grebe Syndrome, which is characterized by short stature, extra digits, and short and deformed extremities. The mature and functional form of Human GDF-5 is a homodimer of two 120 amino-acid polypeptide chain (monomers) linked by a single disulfide bond. Recombinant Human GDF-5 is a 27.0 kDa homodimeric disulfide-linked protein consisting of two 120 amino acid polypeptide chains.
Description
Human GDF-5 is expressed in long bones during embryonic development and postnatally in articular cartilage. Mutations in the Human GDF-5 gene have been implicated in Hunter-Thompson type dwarfism and in Grebe Syndrome, which is characterized by short stature, extra digits, and short and deformed extremities. The mature and functional form of Human GDF-5 is a homodimer of two 120 amino-acid polypeptide chain (monomers) linked by a single disulfide bond. Recombinant Human GDF-5 is a 27.0 kDa homodimeric disulfide-linked protein consisting of two 120 amino acid polypeptide chains.
Product Name Alternative
Growth differentiation factor 5; Growth/differentiation factor 5; H-GDF-5
Gene ID
8200
Accession Number
P43026
Tag
GDF5
Type
Cytokines and proteins
Applications
No tag
Purity
> 98 % as determined by SDS-PAGE
Activity
Testing in progress
Molecular Weight
13.5 kDa
Precautions
The product listed herein is for research use only and is not intended for use in human or clinical diagnosis. Suggested applications of our products are not recommendations to use our products in violation of any patent or as a license. We cannot be responsible for patent infringements or other violations that may occur with the use of this product.
Features & Benefits
Endotoxin: < 1 EU per μg of the protein as determined by the LAL method.
Shipping Conditions
Gel pack with blue ice.
Storage Conditions
Lyophilized recombinant Human GDF5 protein product should be stored desiccated below -20°C. Upon reconstitution, the protein should be stored at 4°C between 2-7 days and for future use below -20°C. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA) . Please prevent freeze-thaw cycles.
Protein Length
The recombinant Human GDF5 consists of 120 amino acids and predicts a molecular mass of 13.5 kDa.
Formulation
Lyophilized from 40 mM Tris-HCl pH 8.0, 50 mM NaCl.
Applications Notes
Human
Other Product Names
Growth differentiation factor 5; Growth/differentiation factor 5; H-GDF-5
Recommended Usage
Centrifuge tubes before opening. It is recommended to reconstitute the lyophilized recombinant Human GDF5 protein using the buffer we provided not less than 100 µg/ml, which can then be further diluted to other aqueous solutions.
Preparation
E. coli
Accession Number URL
http://www.uniprot.org/uniprot/P43026
AA Sequence
Amino acid sequence derived from Human GDF5 (Ala382-Arg501) (P43026) was expressed.

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