Products for Research Use Only

Human NT-3 Protein

CAT: 0749-PRP1044-01Size: 10 µgDry Ice: NoHazardous: No
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CAT#:0749-PRP1044-01Size:10 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
Human Neurotrophin-3 (NT-3) is a member of the neurotrophin family, that controls the survival and differentiation of mammalian neurons. This protein is closely related to both nerve growth factor and brain-derived neurotrophic factor. NT-3 is a key mediator of neuronal development during the early neurogenic period. NT-3 is a novel target gene of POU3F2 and that the POU3F2/NT-3 pathway plays a role in the process of neuronal differentiation. NT-3 is capable of activating TrkB to induce anoikis resistance, and show that NT-3 is also a direct target of miR-200c. NT-3 is broadly expressed in the ovary, spleen, and other tissues. Diseases associated with NT-3 include Hypochondriasis and Demyelinating Disease.
Description
Human Human NT-3 Protein, expressed in E. coli
Product Name Alternative
HDNF ; NGF-2 ; NGF2 ; NT-3; NT3
Gene ID
4908
Accession Number
P20783
Tag
NT-3
Type
Cytokines and proteins
Applications
No tag
Purity
> 96% as determined by SDS-PAGE
Molecular Weight
16 kDa
Precautions
The product listed herein is for research use only and is not intended for use in human or clinical diagnosis. Suggested applications of our products are not recommendations to use our products in violation of any patent or as a license. We cannot be responsible for patent infringements or other violations that may occur with the use of this product.
Features & Benefits
Endotoxin: <0.1 EU per μg of the protein as determined by the LAL method.
Shipping Conditions
Gel pack with blue ice.
Storage Conditions
Human NT-3 protein product should be stored desiccated below -20°C. The protein should be stored at 4°C between 2-7 days and for future use below -20°C. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA) . Please prevent freeze-thaw cycles.
Protein Length
The recombinant Human NT-3 consists of 119 amino acids with 6 xHis tag at N- terminus and has a predicted molecular mass of 16 kDa.
Formulation
Lyophilized from sterile 20 mM Tris, 10% Glycerol, pH 8.0.
Applications Notes
Human
Other Product Names
Human Human NT-3 Protein; HDNF ; NGF-2 ; NGF2 ; NT-3; NT3
Recommended Usage
Always centrifuge tubes before opening. It is recommended to diluted the protein using the PBS buffer or Protein storage solution to working concentration
Preparation
E. coli
Accession Number URL
http://www.uniprot.org/uniprot/P20783
AA Sequence
Amino acid sequence derived from the processed form of Human NT-3 (P20783-1) (Tyr139-Thr257) was expressed and purified

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