Human BAFF Protein

• Background :

  B lymphocyte stimulator (Blys), also known as TNFSF13B, CD257, and BAFF, is a one -way II membrane protein, which belongs to the tumor necrosis factor family. BAFF is expressed in large quantities in peripheral blood white cells, and is specially expressed in monocytes and macrophages. BAFF is a cellular factor that can be used as a container TNFRSF13B (TACI), TNFRSF17 (BCMA) and TNFRSF13C (BAFFR) . These receptors are important factors for B cell differentiation, stability and choice.Blys level affects the survival signals and selective apoptosis of B cells that produce their own antibodies. Therefore, it is a effective B -cell activist and has been proven to play an important role in the proliferation and differentiation of B cells. Over -expression of BLYS in mice can lead to the clinical and serum characteristics of systemic lupus erythematosus (SLE) and dry syndrome (SS) . Blys is an attractive treatment target in human rheumatism. Blys adjusts the size of the outer peripheral B cell area and the capacity of the library to increase the possibility of Blys and its antagonists that may constitute a three -point method. As a kind of agonist, Blys protein can enhance the immunity that is congenital or obtained immune defects, such as immune defects caused by virus infection or cancer therapy

• Description :

  Human BAFF Protein, expressed in E. coli

• Product Name Alternative :

  BAFF Protein, Human; BLYS Protein, Human; CD257 Protein, Human; DTL Protein, Human; TALL-1 Protein, Human; TALL1 Protein, Human; THANK Protein, Human; TNFSF20 Protein, Human; ZTNF4 Protein, Human

• Gene ID :

  10673

• Accession Number :

  Q96RJ3

• Tag :

  BAFF

• Type :

  Cytokines and proteins

• Applications :

  No tag

• Purity :

  > 99 % as determined by SDS-PAGE

• Activity :

  Immobilized Human BAFF at 1μg/mL (100μl/well) can bind Human BCMA (C-mFc), The EC50 of Human BCMA is 0.2 μg/mL.

• Molecular Weight :

  22.9 kDa

• Precautions :

  The product listed herein is for research use only and is not intended for use in human or clinical diagnosis. Suggested applications of our products are not recommendations to use our products in violation of any patent or as a license. We cannot be responsible for patent infringements or other violations that may occur with the use of this product.

• Features & Benefits :

  Endotoxin: < 1 EU per μg of the protein as determined by the LAL method

• Shipping Conditions :

  Gel pack with blue ice.

• Storage Conditions :

  Lyophilized recombinant Human BAFF protein product should be stored desiccated below -20°C. Upon reconstitution, the protein should be stored at 4°C between 2-7 days and for future use below -20°C. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA) . Please prevent freeze-thaw cycles.

• Protein Length :

  The recombinant Human SHH consists of 152 amino acids with 6xHis tag at N terminus and predicts a molecular mass of 22.9 kDa.

• Formulation :

  Lyophilized from PBS, pH 7.5.

• Applications Notes :

  Human

• Other Product Names :

  BAFF Protein; BLYS Protein; CD257 Protein; DTL Protein; TALL-1 Protein; TALL1 Protein; THANK Protein; TNFSF20 Protein; ZTNF4 Protein

• Recommended Usage :

  Always centrifuge tubes before opening. It is recommended to reconstitute the lyophilized recombinant Human BAFF protein using the buffer we provided not less than 100µg/ml, which can then be further diluted to other aqueous solutions.

• Preparation :

  E. coli

• Accession Number URL :

  https://www.uniprot.org/uniprot/Q96RJ3

• AA Sequence :

  Amino acid sequence derived from Human BAFF (Q9Y275-1) (Ala 134-Leu 285) was expressed.