Collagen Type I, mouse

Collagen Type I, mouse

• Background: Type I Collagen usually exists as a heterotrimer formed by alpha 1(I) and alpha 2(I) chains and is found in bone, cornea, skin and tendon. In foetal tissues also homotrimers of alpha-1(I) are found, but they are not constituents of normal adult tissues. Collagens consist of a family of highly specialized glycoproteins of which at least 16 genetically distinct types are known to date. The basal unit of a collagen molecule consists of a triple-helical structure formed by 3 alpha-chains. Predominant amino acids are glycine, proline and hydroxproline. Regularly also lysines and hydroxylysines occur, which are responsible for cross-linkage and glycosylation of the protein chains. Different composition of alpha-chains and different glycosylation contribute to the high variability of collagens in different tissues and organs. Mouse collagen type I 100%, mouse collagen type II and IV <0.1%; mouse collage type III <1%; .
• UniProt: P11087
• Host: Rabbit
• Applications: IHC (paraffin), IF, ELISA, Radioimmunoassay, WB
• Field of Research: Extracellular matrix
• Purification Method: affinity purified antibody lyophilized from phosphate buffered solution; no BSA and preservative added!
• Assay Principle: IHC(P), IFA, ELISA, RIA, IB/WB
• Concentration: 1 mg/mL
• Form: affinity purified antibody lyophilized from phosphate buffered solution; No BSA and preservative added
• Precautions: *These antibodies are intended for in vitro research use only. They must not be used for clinical diagnostics and not for in vivo experiments in Humans or animals.
• References & Citations: 1. Demarchez M., Hartmann D.J., Herbage D., Ville G., Prunieras M. (1987) Wound-healing of Human-skin transplanted onto the nude-mouse. 2. an immunohistological and ultrastructural study of the epidermal basement-membrane zone reconstruction and connective-t 2. Duprez A., Guerret S., Vignaud J.M., Plenat F., Hartmann D.J., Grimaud J.A. (1987) The interstitial matrix of Human carcinomas and sarcomas transplanted to the nude mouse : immunolocalization of some Human and murine components. Cell. Mol. Biol. 33, 647-6 3. Andujar M.B., Hartmann D.J., Emonard H., Magloire H. (1988) Distribution and synthesis of type I and type III collagens in developing mouse molar tooth root. Histochemistry 88, 131-140. 4. Plenat F., Vignaud J.M., Guerret-Stocker S., Hartmann D., Duprez K., Duprez A. (1992) Host-Donor interactions in healing of Human split-thickness skin grafts onto nude mice: in situ hybridization, immunohistochemical, and histochemical studies. Transplant
• Storage Conditions: -20°C