NH2-bicyclo[1.1.1]pentane-7-MAD-MDCPT (hydrochloride)

• UNSPSC Description:

  NH2-bicyclo[1.1.1]pentane-7-MAD-MDCPT (compound I) hydrochloride is a topoisomerase I inhibitor, which can be delivered to cells through conjugated antibody targeting, and has good ADC activity in vivo and in vitro[1].

• Target Antigen:

  ADC Cytotoxin; Topoisomerase

• Type:

  Reference compound

• Related Pathways:

  Antibody-drug Conjugate/ADC Related;Cell Cycle/DNA Damage

• Applications:

  Cancer-programmed cell death

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/nh2-bicyclo-1-1-1-pentane-7-mad-mdcpt-hydrochloride.html

• Solubility:

  DMSO : 100 mg/mL (ultrasonic)

• Smiles:

  NC12CC(C2)(C3=C4C(C(N5C4)=CC([C@](O)(C(OC6)=O)CC)=C6C5=O)=NC7=CC(OCO8)=C8C=C73)C1.[H]Cl

• Molecular Weight:

  509.94

• References & Citations:

  [1]Andrew C. Phillips, et al. Anti-c-met antibody drug conjugates.WO2022232834.

• Shipping Conditions:

  Room Temperature

• Clinical Information:

  No Development Reported