Elacridar

• UNSPSC Description:

  Elacridar is an orally active P-glycoprotein (Pgp) and breast cancer resistance protein (BCRP) inhibitor. Elacridar can be used to examine the influence of efflux transporters on agent distribution to brain and the research of cancer[1][2].

• Target Antigen:

  BCRP; P-glycoprotein

• Type:

  Reference compound

• Related Pathways:

  Membrane Transporter/Ion Channel

• Applications:

  Cancer-programmed cell death

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/elacridar.html

• Purity:

  99.94

• Solubility:

  DMSO : 5 mg/mL (ultrasonic)

• Smiles:

  O=C1C2=CC=CC(C(NC(C=C3)=CC=C3CCN4CC(C=C(C(OC)=C5)OC)=C5CC4)=O)=C2NC6=C1C=CC=C6OC

• Molecular Weight:

  563.64

• References & Citations:

  [1]Sane R, et al. Brain distribution and bioavailability of elacridar after different routes of administration in the mouse. Drug Metab Dispos. 2012 Aug;40(8):1612-9.|[2]Sato H, et al. Elacridar enhances the cytotoxic effects of sunitinib and prevents multidrug resistance in renal carcinoma cells. Eur J Pharmacol. 2015 Jan 5;746:258-66.Antiviral Res. 2021 Jun 28;105124.|Biomed Pharmacother. 2020 Sep;129:110506.|Biomed Res Int. 2020 Nov 29;2020:8878158.|Cell Death Dis. 2021 Jul 27;12(8):742.|Cell Death Dis. 2019 May 24;10(6):400. |Cell Metab. 2024 Mar 5;36(3):498-510.e11.|Cell Rep. 2020 Jun 23;31(12):107782.|Clin Cancer Res. 2018 Jan 15;24(2):383-394.|EJNMMI Res. 2015 Mar 17;5:11. |Eur J Med Chem. 2023 Aug 17;260:115721.|Hong Kong Polytechnic University. Department of Applied Biology and Chemical Technology. 2022 Oct.|Int J Biol Macromol. 2024 Feb 21;264(Pt 1):130377.|Int J Mol Sci. 2019 Mar 5;20(5). pii: E1125. |J Agric Food Chem. 2019 Feb 27;67(8):2350-2360.|J Agric Food Chem. 2022 Feb 3.|J Biol Chem. 2022 Aug 6;102353.|J Drug Target. 2016;24(5):441-9.|Molecules. 2019 Apr 27;24(9):1661. |Preprints. 2024 Jun 19.|Sci Adv. 2023 Oct 20;9(42):eabp9530.|Sci Rep. 2021 Jul 22;11(1):14948.|Crit Rev Anal Chem. 2021 Mar 10;1-15.|Food Chem Toxicol. 2021, 112381.|J Mater Chem B. 2018 Dec 7;6(45):7521-7529. |Mol Psychiatry. 2023 Oct 16.|Xenobiotica. 2024 Aug 10:1-15.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  -20°C, 3 years; 4°C, 2 years (Powder)

• Clinical Information:

  Phase 1

• CAS Number:

  143664-11-3