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NSC23925

CAT: 0804-HY-19626-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-19626-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
NSC23925 is a novel, selective and effective P-glycoprotein (Pgp) inhibitor.
CAS Number
858474-14-3
UNSPSC
12352005
Hazard Statement
H301
Target
P-glycoprotein
Type
Reference compound
Related Pathways
Membrane Transporter/Ion Channel
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/NSC23925.html
Purity
99.43
Solubility
DMSO : 14.29 mg/mL (ultrasonic; warming; heat to 80°C) |H2O : 4 mg/mL (ultrasonic; warming; heat to 80°C)
Smiles
OC(C1NCCCC1)C2=CC(C3=CC=C(OC)C=C3)=NC4=CC=CC=C24.[H]Cl.[H]Cl
Molecular Formula
C22H26Cl2N2O2
Molecular Weight
421.36
Precautions
H301
References & Citations
[1]Yang X, et al. Nsc23925 prevents the development of paclitaxel resistance by inhibiting the introduction of P-glycoprotein and enhancing apoptosis. Int J Cancer. 2015 Oct 15;137 (8) :2029-39.|[2]Duan Z, et al. NSC23925, identified in a high-throughput cell-based screen, reverses multidrug resistance. PLoS One. 2009 Oct 12;4 (10) :e7415.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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