(+) -Sotalol

• Description :

  (+) -Sotalol ((S) -Sotalol) is the S-isomer of Sotalol (HY-103196) . Sotalol is an orally active, non-selective β-adrenergic receptor blocker. (+) -Sotalol is an antiarrhythmic agent. (+) -Sotalol can prolong action potential duration in isolated cardiac muscle[1][2][3].

• Product Name Alternative :

  (S) -Sotalol

• UNSPSC :

  12352005

• Target :

  Adrenergic Receptor

• Type :

  Reference compound

• Related Pathways :

  GPCR/G Protein; Neuronal Signaling

• Field of Research :

  Neurological Disease; Cardiovascular Disease

• Assay Protocol :

  https://www.medchemexpress.com/plus-sotalol.html

• Concentration :

  10mM

• Purity :

  99.89

• Solubility :

  DMSO : 100 mg/mL (ultrasonic)

• Smiles :

  CC(C)NC[C@H](C1=CC=C(C=C1)NS(C)(=O)=O)O

• Molecular Formula :

  C12H20N2O3S

• Molecular Weight :

  272.36

• References & Citations :

  [1]ChuanjunLu, et al. The Ru-catalyzed enantioselective preparation of chiral halohydrins and their application in the synthesis of (R) -clorprenaline and (S) -sotalol. Tetrahedron: Asymmetry.Volume 22, Issue 7.11 April 2011, Pages 722-727|[2]Kato R, et al. Electrophysiologic effects of the levo- and dextrorotatory isomers of sotalol in isolated cardiac muscle and their in vivo pharmacokinetics. J Am Coll Cardiol. 1986 Jan;7 (1) :116-25. |[3]Lynch JJ, et al. Antiarrhythmic and antifibrillatory actions of the levo- and dextrorotatory isomers of sotalol. J Cardiovasc Pharmacol. 1984 Nov-Dec;6 (6) :1132-41.|[4]Serge Sicouri, et al. d-Sotalol Induces Marked Action Potential Prolongation and Early Afterdepolarizations in M but Not Epicardial or Endocardial Cells of the Canine Ventricle. Journal of Cardiovascular Pharmacology and Therapeuticshttps. 2016.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• Isoform :

  β adrenergic receptor

• CAS Number :

  [30236-32-9]