(+) -Sotalol

CAT: 0804-HY-126028A-01Size: 5 mgDry Ice: NoHazardous: No

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CAT#:0804-HY-126028A-01Size:5 mg

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Description

(+) -Sotalol ((S) -Sotalol) is the S-isomer of Sotalol. Sotalol is an orally active, non-selective β-adrenergic receptor blocker. (+) -Sotalol is an antiarrhythmic agent. (+) -Sotalol can prolong action potential duration in isolated cardiac muscle[1][2][3].

CAS Number

30236-32-9

Product Name Alternative

(S) -Sotalol

UNSPSC

12352005

Target

Adrenergic Receptor

Type

Reference compound

Related Pathways

GPCR/G Protein; Neuronal Signaling

Field of Research

Neurological Disease; Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/plus-sotalol.html

Concentration

10mM

Purity

99.89

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

CC(C)NC[C@H](C1=CC=C(C=C1)NS(C)(=O)=O)O

Molecular Formula

C12H20N2O3S

Molecular Weight

272.36

References & Citations

[1]ChuanjunLu, et al. The Ru-catalyzed enantioselective preparation of chiral halohydrins and their application in the synthesis of (R) -clorprenaline and (S) -sotalol. Tetrahedron: Asymmetry.Volume 22, Issue 7.11 April 2011, Pages 722-727|[2]Kato R, et al. Electrophysiologic effects of the levo- and dextrorotatory isomers of sotalol in isolated cardiac muscle and their in vivo pharmacokinetics. J Am Coll Cardiol. 1986 Jan;7 (1) :116-25. |[3]Lynch JJ, et al. Antiarrhythmic and antifibrillatory actions of the levo- and dextrorotatory isomers of sotalol. J Cardiovasc Pharmacol. 1984 Nov-Dec;6 (6) :1132-41.|[4]Serge Sicouri, et al. d-Sotalol Induces Marked Action Potential Prolongation and Early Afterdepolarizations in M but Not Epicardial or Endocardial Cells of the Canine Ventricle. Journal of Cardiovascular Pharmacology and Therapeuticshttps. 2016.

Shipping Conditions

Room Temperature

Storage Conditions

-20°C, 3 years; 4°C, 2 years (Powder)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Isoform

β adrenergic receptor

Alternative Products

Catalog	Name
B1367-100	Sotalol
MBS5774695-01	(-)-Sotalol
T72980	(+) -Sotalol
FS61454-01	Sotalol HCl
T0483-01	Sotalol hydrochloride
AR-S10682-01	Sotalol-d6

(+) -Sotalol

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