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Omadacycline

CAT: 0804-HY-14865-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-14865-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Omadacycline (PTK 0796), a first-in-class orally active aminomethylcycline antibacterial, is a member of the tetracycline class of antibiotics. Omadacycline acts through the inhibition of bacterial protein synthesis by binding to the 30S ribosomal subunit. Omadacycline possesses broad-spectrum antibacterial activity against aerobic and anaerobic Gram-positive and Gram-negative bacteria, as well as atypical bacteria. Omadacycline can be used for the research of acute bacterial skin and skin-structure infections, community-acquired pneumonia, and urinary tract infections[1][2][3][4].
CAS Number
389139-89-3
Product Name Alternative
PTK 0796; Amadacycline
UNSPSC
12352005
Hazard Statement
H361-H362
Target
Antibiotic; Bacterial
Type
Reference compound
Related Pathways
Anti-infection
Applications
COVID-19-immunoregulation
Field of Research
Infection
Assay Protocol
https://www.medchemexpress.com/omadacycline.html
Purity
99.85
Solubility
DMSO : 100 mg/mL (ultrasonic) |Methanol : 125 mg/mL (ultrasonic)
Smiles
O=C(C1=C(O)[C@@H](N(C)C)[C@@](C[C@@]2([H])C(C(C3=C(O)C(CNCC(C)(C)C)=CC(N(C)C)=C3C2)=O)=C4O)([H])[C@@]4(O)C1=O)N
Molecular Formula
C29H40N4O7
Molecular Weight
556.65
Precautions
P260-P263-P264-P270-P280-P405-P501
References & Citations
[1]Durães F, et, al. Omadacycline: A Newly Approved Antibacterial from the Class of Tetracyclines. Pharmaceuticals (Basel) . 2019 Apr 21;12 (2) :63.|[2]Macone AB, et, al. In vitro and in vivo antibacterial activities of omadacycline, a novel aminomethylcycline. Antimicrob Agents Chemother. 2014;58 (2) :1127-35.|[3]Zhanel GG, et, al. Omadacycline: A Novel Oral and Intravenous Aminomethylcycline Antibiotic Agent. Drugs. 2020 Feb;80 (3) :285-313.|[4]Markham A, et, al. Omadacycline: First Global Approval. Drugs. 2018 Dec;78 (18) :1931-1937.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C (Powder, sealed storage, away from moisture and light)
Scientific Category
Reference compound1
Clinical Information
Launched
Isoform
Tetracycline
Citation 01
Animal Feed Science and Technology. 2014 Dec;198:323-332.|Ann Lab Med. 2021 May 1;41 (3) :293-301.|Antibiotics (Basel) . 2022 Sep 23;11 (10) :1298.|Antimicrob Agents Chemother. 2019 May 24;63 (6) . pii: e00470-19.|Antimicrob Agents Chemother. 2020 Feb 21;64 (3) :e02097-19.|Antimicrob Agents Chemother. 2023 Feb 16;67 (2) :e0145922.|Antimicrob Agents Chemother. 2024 Oct 29:e0105124.|Antimicrob Agents Chemother. 2025 May 23:e0024925.|Clin Exp Pharmacol Physiol. 2023 Jul;50 (7) :604-609.|Comput Intell Neurosci. 2022 Apr 25;2022:7636983.|Cureus. 2024 Dec 1;16 (12) :e74917.|Diagn Micr Infec Dis. 2020 Nov;98 (3) :115129.|Infect Drug Resist. 2025 Oct 4:18:5239-5247.|J Antibiot (Tokyo) . 2022 Aug;75 (8) :463-471.|J Clin Microbiol. 2020 Jan 28;58 (2) :e01603-19.|J Glob Antimicrob Resist. 2025 Aug 8:44:435-441.|J Microbiol Immunol Infect. 2025 Apr;58 (2) :219-225.|Malar J. 2025 Jun 19;24 (1) :194.|Microbiol Spectr. 2023 Feb 14;11 (1) :e0323822.|Microbiol Spectr. 2023 Jun 15;11 (3) :e0071823.|Nat Microbiol. 2023 Mar;8 (3) :410-423.|Nat Struct Mol Biol. 2023 Sep;30 (9) :1380-1392.|Open Forum Infect Dis. 2024 Oct 11;11 (11) :ofae611.|PLoS Biol. 2022 Sep 28;20 (9) :e3001808.|Research Square Preprint. 2020 Jun.|Antimicrob Agents Chemother. 2024 Jul 9;68 (7) :e0063824.|J Antimicrob Chemother. 2021 Feb 11;76 (3) :653-658.|J Antimicrob Chemother. 2021 Jul 15;76 (8) :2071-2078.|Virulence. 2022 Dec;13 (1) :77-88.

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