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Alpha Synuclein A53T Mutant Monomers

CAT: 0013-GTR19032575Size: 100 µgDry Ice: NoHazardous: No
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CAT#:0013-GTR19032575Size:100 µg
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Description
Human Recombinant Alpha Synuclein A53T Mutant Monomers (Type 1)
Product Name Alternative
A53T mutant alpha synuclein, A53T mutated SNCA, A53T Alpha synuclein monomer, Ala53thr mutant alpha synuclein, Alpha synuclein protein, Alpha-synuclein protein, Non-A beta component of AD amyloid protein, Non-A4 component of amyloid precursor protein, NACP protein, SNCA protein, NACP protein, PARK1 protein, Alpha synuclein monomers, SYN protein, Parkinson disease familial 1 Protein
UniProt
P37840
Reactivity
Human
Tag
No tag
Source
Recombinant
Origin
Human
Field of Research
Neuroscience
Concentration
2 mg/ml
Purity
>95%
Bioactivity
100 μM A53T alpha synuclein protein monomer seeded with 10 uM A53T alpha synuclein protein PFF in 25 μM Thioflavin T (PBS pH 7.4, 100 μl reaction volume) generated a fluorescence intensity of 28 000 Relative Fluorescence Units after incubation at 37°C with shaking at 600 rpm for 56 hours. Fluorescence was measured by excitation at 450 nm and emission at 485 nm on a Molecular Devices Gemini XPS microplate reader.
Molecular Weight
~14.46 kDa
Storage Conditions
-80°C
Notes
For research use only.
Applications Notes
Certified >95% pure using SDS-PAGE analysis. Low endotoxin <5 EU/mL @ 2mg/mL.
Tested Applications
In vitro, In vivo, SDS-PAGE, WB
Preservative
PBS pH 7.4
AA Sequence
MDVFMKGLSK AKEGVVAAAE KTKQGVAEAA GKTKEGVLYV GSKTKEGVVH GVTTVAEKTK EQVTNVGGAV VTGVTAVAQK TVEGAGSIAA ATGFVKKDQL GKNEEGAPQE GILEDMPVDP DNEAYEMPSE EGYQDYEPEA

UniProtKB · P37840

Alpha-synuclein

SYUA_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
P37840
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
SNCA
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
—
EC number
—
Processing
—
Secondary accessions
A8K2A4, Q13701, Q4JHI3, Q6IAU6
Protein keywords

Technical term

3D-structureDirect protein sequencingProteomics identificationReference proteome

PTM

AcetylationPhosphoproteinUbl conjugation

Coding sequence diversity

Alternative splicing

Disease

Alzheimer diseaseDisease variantNeurodegenerationParkinson diseaseParkinsonism

Cellular component

AmyloidCell projectionCytoplasmMembraneNucleusSecretedSynapse

Ligand

CopperMetal-binding

Domain

Repeat

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