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P140

CAT: 0013-GTR19032552Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19032552Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
P140 is a peptide from the small nuclear ribonucleoprotein U1-70K, phosphorylated at the Ser140 position. P140 binds to the HSPA8/HSC70 chaperone protein, a constitutively expressed, cognate protein of the HSP70 family, which is involved in many cellular processes and has a key regulatory role in autophagy. Both in vitro and in vivo, P140 interferes with hyperactivated chaperone-mediated autophagy, modifying overexpression of major histocompatibility complex class II molecules and antigen presentation to autoreactive T cells. In a lupus prone murine model, P140 displays tolerogenic and immunomodulatory effects, depleting hyperactivated autoreactive T and B cells and restoring normal immune homeostasis. P140 decreases proteinuria and anti-DNA antibody production, and significantly prolongs survival.
Product Name Alternative
Phosphopeptide P140, CEP 33457, Forigerimod, IPP 201101
Purity
>95% by hplc
Form
Freeze dried solid
Solubility
Soluble in water
Molecular Weight
2638.94 Da
Storage Conditions
Store dry, frozen and in the dark
Notes
For research use only.
AA Sequence
H-Arg-Ile-His-Met-Val-Tyr-Ser-Lys-Arg-Ser- (PO3) -Gly-Lys-Pro-Arg-Gly-Tyr-Ala-Phe-Ile-Glu-Tyr-OH

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