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Human interleukin 1β

CAT: 0013-GTR19030870Size: 100 µgDry Ice: NoHazardous: No
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CAT#:0013-GTR19030870Size:100 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
This protein is produced by a wide variety of cells in response to inflammatory agents, infections, or microbial endotoxins. While IL-1 alpha and IL-1 beta are regulated independently, they bind to the same receptor and exert identical biological effects. IL-1 RI binds directly to IL-1 alpha or IL-1 beta and then associates with IL-1 R accessory protein (IL-1 R3/IL-1 R AcP) to form a high-affinity receptor complex that is competent for signal transduction. The human IL-1 beta cDNA encodes a 269 aa precursor. A 116 aa propeptide is cleaved intracellularly by the cysteine protease IL-1 beta -converting enzyme (Caspase-1/ICE) to generate the active cytokine. The 17 kDa mature human IL-1 beta shares >80 % aa sequence identity with mouse IL-1 beta
Product Name Alternative
IL1B, IL1F2
Reactivity
Human, Mouse
Conjugation
Unconjugated
Tag
Histidine
Source
E.coli
Origin
Recombinant protein expressed as His tage protein in E.coli
Field of Research
Immunology & Inflammation
Concentration
1mg/mL
Dilution
NA
Endotoxin
Not tested
Purity
≥98%
Form
Lyophilized
Solubility
Soluble in PBS at 25°C
Molecular Weight
~17 kDa
Storage Conditions
After reconstitution, store at -20°C; Avoid repeated freeze thaw
Notes
For research use only.
Applications Notes
For research use only
Tested Applications
SDS-PAGE
Host or Source
E. coli
Preservative
No preservative
AA Sequence
APVRSLNCTLRDSQQKSLVMSGPYELKALHLQGQDMEQQVVFSMSFVQGEESNDKIPVALGLKEKNLYLSCVLKDDKPTLQLESVDPKNYPKKKMEKRFVFNKIEINNKLFESAQFPNWYISTSQAENMPVFLGGTKGGQDITDFTMQFVSS

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