Recombinant Rat JAM-B/CD322 Protein (His Tag)

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Dry Ice Shipment: No

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Alternative Products

Cat	Name
HY-P70385-02	JAM-B/CD322, Human (HEK293, His)
HY-P70385-01	JAM-B/CD322, Human (HEK293, His)
HY-P73852	JAM-B/CD322, Rat (HEK293, Fc)
HY-P73261-05	JAM-B/CD322, Rat (HEK293, His)
HY-P73261-02	JAM-B/CD322, Rat (HEK293, His)
HY-P73261-01	JAM-B/CD322, Rat (HEK293, His)
HY-P73260-06	JAM-B/CD322, Mouse (HEK293, His)
HY-P73260-02	JAM-B/CD322, Mouse (HEK293, His)
HY-P73260-01	JAM-B/CD322, Mouse (HEK293, His)
HY-P73259	JAM-B/CD322, Mouse (HEK293, Fc)

Recombinant Rat JAM-B/CD322 Protein (His Tag)

CAT:

763-PKSR030196

Size:

100 µg

Price:

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For price, please contact [email protected].

Recombinant Rat JAM-B/CD322 Protein (His Tag)

Background: Junctional adhesion molecule B (JAM-B), also known as Junctional adhesion molecule 2 (JAM2), Vascular endothelial junction-associated molecule (VE-JAM), and CD322, is a single-pass type I membrane protein which belongs to the immunoglobulin superfamily. It is prominently expressed on high endothelial venules. expression to be restricted to the high endothelial venule of tonsil and lymph nodes. The localization to the endothelium of arterioles in and around inflammatory and tumor foci. JAM-B can function as an adhesive ligand for the T cell line J45 and can interact with GM-CSF/IL-4-derived peripheral blood dendritic cells, circulating CD56(+) NK cells, circulating CD56(+)CD3(+) NK/T cells, and circulating CD56(+)CD3(+)CD8(+) cytolytic T cells. JAM-2 is expressed on high endothelial venules (HEVs) in human tonsil and on a subset of human leukocytes, suggesting that JAM-2 plays a central role in the regulation of transendothelial migration. It binds to very late activation antigen (VLA)-4, a leucocyte integrin that contributes to rolling and firm adhesion of lymphocytes to endothelial cells through binding to vascular cell adhesion molecule (VCAM)-1. JAM-B appears to contribute to leucocyte extravasation by facilitating not only transmigration but also rolling and adhesion. JAM-B acts as an adhesive ligand for interacting with a variety of immune cell types and may play a role in lymphocyte homing to secondary lymphoid organs.
Synonyms: JAM-2, JAM2
UniProt: Q3MHC0
Accession Number: Q3MHC0
Host: HEK293 Cells
Origin Species: Rat
Tag: C-His
Sequence: Met1-Asn236
Applications: Cell culture
Purity: > 90 % as determined by reducing SDS-PAGE.
Bioactivity: Measured by the ability of the immobilized protein to support the adhesion of Jurkat human acute T cell leukemia cells. When cells (8 x 10⁴cells/well) are added to rat JAM2-His coated plates (5 μg/mL, 100 μL/well), > 30% will adhere after 60 minutes at 37°C.
Reconstitution: Please refer to the printed manual for detailed information.
Molecular Weight: 43 kDa
Shipping Conditions: This product is provided as lyophilized powder which is shipped with ice packs.
Storage Conditions: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

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Cat	Name
PKSH032663-01	Recombinant Human JAM-B/CD322 Protein (Fc Tag)
PKSR030197	Recombinant Rat JAM-B/CD322 Protein (Fc Tag)
PKSH032662-01	Recombinant Human JAM-B/CD322 Protein (His Tag)
PKSH032663-02	Recombinant Human JAM-B/CD322 Protein (Fc Tag)
PKSH032662-02	Recombinant Human JAM-B/CD322 Protein (His Tag)
PKSR030196	Recombinant Rat JAM-B/CD322 Protein (His Tag)
PKSM040668	Recombinant Mouse JAM2/CD322 Protein (His Tag)
PKSH033607-02	Recombinant Human JAM-A/F11R Protein (His Tag)
PKSH031772	Recombinant Human JAM-A/F11R Protein (Fc Tag)
PKSM040670	Recombinant Mouse JAM-A/F11R Protein (Fc Tag)