Recombinant Cynomolgus BCMA/TNFRSF17 (C-6His)

Recombinant Cynomolgus BCMA/TNFRSF17 (C-6His)

• Background: B cell maturation antigen (BCMA) is a member of the TNF receptor superfamily. It has been designated TNFRSF17. BCMA is a type III membrane protein containing one extracellular cysteine rich domain. Within the TNFRSF, it shares the highest homology with TACI. BCMA and TACI have both been shown to bind to APRIL and BAFF, members of the TNF ligand superfamily. BCMA expression has been found in immune organs and mature B cell lines. Although some expression has been observed at the cell surface, BCMA appears to be localized to the Golgi compartment. The binding of BCMA to APRIL or BAFF has been shown to stimulate IgM production in peripheral blood B cells and increase the survival of cultured B cells. This data suggests that BCMA may play an important role in B cell development,function and regulation.
• Abbreviation: BCMA;TNFRSF17
• Synonyms: B-cell maturation protein, Bcm, Bcma, CD269, Tnfrsf17, Tumor necrosis factor receptor superfamily member 17
• CAS Number: 9000-83-3
• UniProt: G7Q0I4
• Accession Number: G7Q0I4
• Host: HEK293 Cells
• Origin Species: Cynomolgus macaques
• Tag: C-His
• Sequence: Met1-Ala53
• Purity: > 90 % as determined by reducing SDS-PAGE.
• Bioactivity: Not validated for activity
• Reconstitution: Please refer to the printed manual for detailed information.
• Molecular Weight: 12&15-20 kDa
• Shipping Conditions: This product is provided as lyophilized powder which is shipped with ice packs.
• Storage Conditions: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.