Recombinant Rhesus macaque CD47/IAP Protein (Fc Tag)

• Background:

  CD47 (Integrin-Associated Protein, IAP) is a 40-60 kDa variably glycosylated atypical member of the immunoglobulin superfamily. The ubiquitously expressed CD47 binds to SIRP family members on macrophages, neutrophils, and T cells. CD47 is involved in the increase in intracellular calcium concentration that occurs upon cell adhesion to extracellular matrix. The protein is also a receptor for the C-terminal cell-binding domain of thrombospondin, and it may play a role in membrane transport and signal transduction. This protein has broad tissue distribution, and is reduced in expression on Rh erythrocytes.

• Abbreviation:

  CD47; IAP

• Synonyms:

  Antigenic Surface Determinant Protein OA3; CD47; IAP; Integrin-Associated Protein; Leukocyte Surface Antigen CD47; MER6; Protein MER6

• UniProt:

  F7A802

• Accession Number:

  F7A802

• Expression System:

  HEK293 Cells

• Tag:

  C-Fc

• Sequence:

  Gln19-Pro139

• Endotoxin:

  < 1.0 EU per μg of the protein as determined by the LAL method.

• Purity:

  > 95 % as determined by reducing SDS-PAGE.

• Bioactivity:

  Not validated for activity

• Reconstitution:

  Please refer to the printed manual for detailed information.

• Shipping Conditions:

  This product is provided as lyophilized powder which is shipped with ice packs.

• Storage Conditions:

  Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

• Calculated Molecular Weight:

  40.8 kDa

• Observed Molecular Weight:

  60-90 kDa

• Species:

  Rhesus macaque