Recombinant Cynomolgus B7-H3/CD276 Protein (Fc Tag)

Recombinant Cynomolgus B7-H3/CD276 Protein (Fc Tag)

• Background: CD276, also known as B7-H3, is a member of the B7 superfamily with signature IgV and IgG regions in extracellular domains. It is a type I transmembrane protein and shares 20–27% amino acid identity with other B7 family members. B7-H3 is involved in the activation of T lymphocytes, and regulates murine bone formation. It is also reported that B7-H3 may play an important role in muscle-immune interactions, providing further evidence of the active role of muscle cells in local immunoregulatory processes. B7-H3 is expressed on T-cells, natural killer cells, and antigen presenting cells, as well as some non-immune cells, such as osteoblasts, fibroblasts, fibroblast-like synoviocytes and epithelial cells. High expression of B7-H3 in tumor vasculature also correlates with poor survival in patients, suggesting that it may play a role in tumor cell migration.
• Abbreviation: B7-H3;CD276
• Synonyms: B7 homolog 3, B7-H3, CD276, CD276 antigen
• CAS Number: 9000-83-3
• UniProt: A0A7N9CYV2
• Accession Number: XP_015308534
• Host: HEK293 Cells
• Origin Species: Cynomolgus macaques
• Tag: C-Fc
• Sequence: Leu29-Glu465
• Purity: > 95 % as determined by reducing SDS-PAGE.
• Bioactivity: Not validated for activity
• Reconstitution: Please refer to the printed manual for detailed information.
• Molecular Weight: 100-130 kDa
• Shipping Conditions: This product is provided as lyophilized powder which is shipped with ice packs.
• Storage Conditions: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.