Recombinant Cynomolgus CSF1R/CD115 Protein (Fc Tag)
CAT:
763-PKSQ050033-01
Size:
50 µg
Price:
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- Availability: 24/48H Stock Items & 2 to 6 Weeks non Stock Items.
- Dry Ice Shipment: No
Recombinant Cynomolgus CSF1R/CD115 Protein (Fc Tag)
- Background: Macrophage colony-stimulating factor 1 receptor (CSF1R) is a member of the type III subfamily of receptor tyrosine kinases that also includes receptors for SCF and PDGF. These receptors each contain five immunoglobulin-like domains in their extracellular domain (ECD) and a split kinase domain in their intracellular region. CSF1R is expressed primarily on cells of the monocyte/macrophage lineage, dendritic cells, stem cells and in the developing placenta. CSF1 and its receptor (CSF1R, product of c-fms proto-oncogene) were initially implicated as essential for normal monocyte development as well as for trophoblastic implantation. It plays an important role in the regulation of osteoclast proliferation and differentiation, the regulation of bone resorption, and is required for normal bone and tooth development. It is required for normal male and female fertility, and for normal development of milk ducts and acinar structures in the mammary gland during pregnancy. Aberrant expression of CSF1 or CSF1R may play a role in inflammatory diseases.
- Abbreviation: CSF1R;CD115
- Synonyms: CD115, CSF-1 receptor, CSF-1-R, CSF-1R, CSF1R, FMS, M-CSF-R, MCSF Receptor, Macrophage colony-stimulating factor 1 receptor, Proto-oncogene c-Fms
- CAS Number: 9000-83-3
- Accession Number: XP_005558297
- Host: HEK293 Cells
- Origin Species: Cynomolgus macaques
- Tag: C-Fc
- Sequence: Ile20-Pro517
- Purity: > 95 % as determined by reducing SDS-PAGE.
- Bioactivity: Not validated for activity
- Reconstitution: Please refer to the printed manual for detailed information.
- Molecular Weight: 105-130 kDa
- Shipping Conditions: This product is provided as lyophilized powder which is shipped with ice packs.
- Storage Conditions: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.