Recombinant Cynomolgus CD3e/CD3ε Protein (Fc Tag)

Recombinant Cynomolgus CD3e/CD3ε Protein (Fc Tag)

• Background: T-cell surface glycoprotein CD3 epsilon chain, also known as CD3E, is a single-pass type I membrane protein. CD3E contains 1 Ig-like (immunoglobulin-like) domain and 1 ITAM domain. CD3E, together with CD3-gamma, CD3-delta and CD3-zeta, and the T-cell receptor alpha/beta and gamma/delta heterodimers, forms the T cell receptor-CD3 complex. The CD3 epsilon subunit of the T cell receptor (TCR) complex contains two defined signaling domains, a proline-rich sequence and an immune tyrosine activation motifs (ITAMs), and this complex undergoes a conformational change upon ligand binding that is thought to be important for the activation of T cells. T cell receptor-CD3 complex plays an important role in coupling antigen recognition to several intracellular signal-transduction pathways. This complex is critical for T-cell development and function, and represents one of the most complex transmembrane receptors. CD3E plays an essential role in T-cell development, and defects in CD3E gene cause severe immunodeficiency. Homozygous mutations in CD3D and CD3E genes lead to a complete block in T-cell development and thus to an early-onset severe combined immunodeficiency phenotype.
• Abbreviation: CD3e;CD3ε
• Synonyms: CD3 epsilon, CD3-epsilon, CD3e, CD3e antigen, CD3e molecule, FLJ18683, T-cell antigen receptor complex, T-cell surfa, T-cell surface antigen T3/Leu-4 epsilon chain, T3E, epsilon (CD3-TCR complex), epsilon polypeptide (TiT3 complex), epsilon subunit of T3
• CAS Number: 9000-83-3
• UniProt: Q95LI5
• Accession Number: Q95LI5
• Host: HEK293 Cells
• Origin Species: Cynomolgus macaques
• Tag: C-Fc
• Sequence: Gln22-Asp117
• Purity: > 95 % as determined by reducing SDS-PAGE.
• Bioactivity: Not validated for activity
• Reconstitution: Please refer to the printed manual for detailed information.
• Molecular Weight: 38-55 kDa
• Shipping Conditions: This product is provided as lyophilized powder which is shipped with ice packs.
• Storage Conditions: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.