Recombinant Cynomolgus TIM-3/HAVCR2 Protein (Fc Tag)

Recombinant Cynomolgus TIM-3/HAVCR2 Protein (Fc Tag)

• Background: T cell immunoglobulin and mucin domain 3 is a member of the TIM family of immune regulating molecules. Mature cynomolgus TIM3 consists of a 182 amino acid (aa)extracellular domain (ECD), a 21 aa transmembrane segment, and a 78 aa cytoplasmic tail. TIM3 is up-regulated on several populations of activated myeloid cells (macrophage, monocyte, dendritic cell, microglia, mast cell) and T cells (Th1, CD8+, NK, Treg). Its binding to Galectin9 induces a range of immunosuppressive functions which enhance immune tolerance and inhibit anti-tumor immunity. TIM3 ligation attenuates CD8+ and Th1 cell responses and promotes the activity of Treg and myeloid derived suppressor cells. TIM3 interactions with Galectin-9 can trigger immune stimulatory effects, such as the coactivation of NK cell cytotoxicity.
• Abbreviation: TIM-3;HAVCR2
• Synonyms: HAVCR2, T cell immunoglobulin and mucin domain3, TIM3, Tim-3
• CAS Number: 9000-83-3
• UniProt: G7P6Q7
• Accession Number: G7P6Q7
• Host: HEK293 Cells
• Origin Species: Cynomolgus macaques
• Tag: C-Fc
• Sequence: Ser22-Arg201
• Purity: > 95 % as determined by reducing SDS-PAGE.
• Bioactivity: Not validated for activity
• Reconstitution: Please refer to the printed manual for detailed information.
• Molecular Weight: 55-75 kDa
• Shipping Conditions: This product is provided as lyophilized powder which is shipped with ice packs.
• Storage Conditions: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.