Recombinant Mouse TrkC/Ntrk3 (C-6His)

Recombinant Mouse TrkC/Ntrk3 (C-6His)

• Background: Three Trk family proteins, TrkA, TrkB, and TrkC, exhibiting different ligand specificities, have been identified. TrkA binds NGF and NT-3, TrkB binds BDNF, NT-3 and NT-4/5, and TrkC only binds NT-3. The primary location of TrkC expression is in the nervous system and, specifically, in regions of the CNS. Low level TrkC expression has also been observed in a wide variety of tissues outside the nervous system. Receptor tyrosine kinase involved in nervous system and probably heart development. Upon binding of its ligand NTF3/neurotrophin-3, NTRK3 autophosphorylates and activates different signaling pathways, including the phosphatidylinositol 3-kinase/AKT and the MAPK pathways, that control cell survival and differentiation.
• Abbreviation: TrkC;Ntrk3
• Synonyms: GP145-TrkC, NT-3 Growth Factor Receptor, Neurotrophic tyrosine kinase receptor type 3, TrkC, TrkC tyrosine kinase, trk-C
• CAS Number: 9000-83-3
• UniProt: Q6VNS1
• Accession Number: Q6VNS1
• Host: HEK293 Cells
• Origin Species: Mouse
• Tag: C-His
• Sequence: Cys32-Thr429
• Purity: > 95 % as determined by reducing SDS-PAGE.
• Bioactivity: Not validated for activity
• Reconstitution: Please refer to the printed manual for detailed information.
• Molecular Weight: 80-110 kDa
• Shipping Conditions: This product is provided as lyophilized powder which is shipped with ice packs.
• Storage Conditions: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.