Recombinant Mouse Pentraxin-related protein PTX3(N-6His)

Recombinant Mouse Pentraxin-related protein PTX3(N-6His)

• Background: Pentraxin-related protein PTX3, also known as Tumor necrosis factor-inducible gene 14 protein (TSG-14), belongs to the pentraxin family. PTX3 plays a role in the regulation of innate resistance to pathogens, inflammatory reactions, possibly clearance of self-components and female fertility. It’s subunit is a disulfide-linked homooctamer that binds to C1q. PTX3 concentration is elevated in the joint fluid of patients with rheumatoid arthritis (RA), indicating that PTX3 may be a potential mediator of immune response. PTX3 may also function in the regulation of the uptake and clearance of apoptotic cells by dendritic cells. An in vivo study showed that PTX3 transgenic mice are more resistant to sepsis and endotoxemia compared to wild-type during inflammatory injury.
• Abbreviation: Pentraxin-relatedPTX3
• Synonyms: PTX3, Pentaxin-related protein PTX3, Pentraxin 3, alpha-induced protein 5, long, pentaxin-related gene, pentraxin 3, pentraxin-3, pentraxin-related gene, pentraxin-related protein PTX3, rapidly induced by IL-1 beta, tumor necrosis factor
• CAS Number: 9000-83-3
• UniProt: P48759
• Accession Number: P48759
• Host: HEK293 Cells
• Origin Species: Mouse
• Tag: N-His
• Sequence: His18-Ser381
• Purity: > 90 % as determined by reducing SDS-PAGE.
• Bioactivity: Not validated for activity
• Reconstitution: Not Applicable
• Molecular Weight: 54 kDa
• Shipping Conditions: This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs. Upon receipt, store it immediately at < - 20°C.
• Storage Conditions: Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.