Recombinant Mouse Angiotensin-Converting Enzyme 2/ACE-2 (C-10His)

• Background:

  Angiotensin-Converting Enzyme 2 (ACE-2) is an integral membrane protein and a zinc metalloprotease of the ACE family, the ACE family includes somatic and germinal ACE. ACE-2 cleaves angiotensins I and II as a carboxypeptidase, ACE-2 converts angiotensin I to angiotensin 1-9, and angiotensin II to angiotensin 1-7. ACE-2 is also able to hydrolyze apelin-13 and dynorphin-13 with high efficiency. ACE-2 can be high expressed in testis, kidney and heart, in colon, small intestine and ovary at moderate levels. Captopril and lisinopril as the classical ACE inhibitor don’t inhibit ACE-2 activity. ACE-2 may play an important role in regulating the heart function.

• Abbreviation:

  ACE2, ACE-2

• Synonyms:

  ACE-Related Carboxypeptidase; ACE2; ACEH; Angiotensin-Converting Enzyme 2; Angiotensin-Converting Enzyme Homolog; Metalloprotease MPROT15

• UniProt:

  Q8R0I0

• Accession Number:

  Q8R0I0

• Expression System:

  HEK293 Cells

• Tag:

  C-His

• Sequence:

  Gln18-Thr740

• Endotoxin:

  < 1.0 EU per μg of the protein as determined by the LAL method.

• Purity:

  > 95 % as determined by reducing SDS-PAGE.

• Bioactivity:

  Not validated for activity

• Reconstitution:

  Not Applicable

• Shipping Conditions:

  This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs. Upon receipt, store it immediately at < - 20°C.

• Storage Conditions:

  Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.

• Calculated Molecular Weight:

  84.9 kDa

• Observed Molecular Weight:

  85 - 110 kDa

• Formulation:

  Supplied as a 0.2 µm filtered solution of 25mM Tris-HCl, 150mM NaCl, 1mM ZnCl₂, pH 7.5.

• Species:

  Mouse