Recombinant Mouse SerpinE2/SERPINE2 Protein (His Tag)

Recombinant Mouse SerpinE2/SERPINE2 Protein (His Tag)

• Background: Serpin E2 is a member of the Serpin superfamily of the serine protease inhibitors. Serpin E2 is apotent inhibitor of thrombin, plasmin and plasminogen activators. It is differentially expressed during neuronal differentiation and is able to transform humanembryonic kidney cells into neuronlikecells. Its over-expressionin mice leads to progressive neuronal and motor dysfunction in these animals. It is also over-expressedin the majority of pancreatic carcinoma as well as gastric and colorectal cancer samples whereas it is weakly expressed in all normal pancreas and chronicpancreatitis tissue samples. It plays an important role in controlling male fertility because its knockout male mice show a marked impairment in fertility from theonset of sexual maturity and its abnormal expression is found in the semen of men with seminal dysfunction.
• Abbreviation: SerpinE2;SERPINE2
• Synonyms: GDN, Glia-derived nexin, PI-7, PN-1, Peptidase inhibitor 7, Pi7, Pn1, Protease nexin 1, Protease nexin I, Serine protease-inhibitor 4, Serpin E2, Spi4
• CAS Number: 9000-83-3
• UniProt: Q07235
• Accession Number: Q07235
• Host: HEK293 Cells
• Origin Species: Mouse
• Tag: C-His
• Sequence: Ser20-Pro397
• Purity: > 95 % as determined by reducing SDS-PAGE.
• Bioactivity: Not validated for activity
• Reconstitution: Not Applicable
• Molecular Weight: 50-55 kDa
• Shipping Conditions: This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs. Upon receipt, store it immediately at < - 20°C.
• Storage Conditions: Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.