Recombinant Mouse Interleukin-11/IL-11 Protein (Fc Tag)

• Background:

  Interleukin-11 (IL-11) is a secreted protein and belongs to the IL-6 superfamily. IL-11 has been demonstrated to improve platelet recovery after chemotherapy-induced thrombocytopenia, induceacute phase proteins, modulate antigen-antibody responses, participate in the regulation of bone cellproliferation and differentiation and could be use as a therapeutic for osteoporosis. IL-11 stimulates the growth of certain lymphocytes and, in the murine model, stimulates an increase in the cortical thickness and strength of long bones. In addition to having lymphopoietic/hematopoietic and osteotrophic properties, it has functions in many other tissues, including the brain, gut, testis and bone.

• Abbreviation:

  Interleukin-11; IL-11

• Synonyms:

  Interleukin; IL-11; Interleukin-11; Zcyto1; Zcyto10; Il11; AGIF; interleukin 11

• UniProt:

  P47873

• Accession Number:

  P47873

• Expression System:

  HEK293 Cells

• Tag:

  C-Fc

• Sequence:

  Pro22-Leu199

• Endotoxin:

  < 1.0 EU per μg of the protein as determined by the LAL method.

• Purity:

  > 95 % as determined by reducing SDS-PAGE.

• Bioactivity:

  Not validated for activity

• Reconstitution:

  Please refer to the printed manual for detailed information.

• Shipping Conditions:

  This product is provided as lyophilized powder which is shipped with ice packs.

• Storage Conditions:

  Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

• Calculated Molecular Weight:

  46.3 kDa

• Observed Molecular Weight:

  50-60 kDa

• Species:

  Mouse